Targeting population groups with heavier burden of hepatocellular carcinoma incidence : a nationwide descriptive epidemiological study in Sweden
Vaz, Juan LU
; Midlöv, Patrik
LU
; Eilard, Malin Sternby
; Eriksson, Berne
; Buchebner, David
LU
and Strömberg, Ulf
LU
(2022)
In International Journal of Cancer
151(2).
p.229-239
- Abstract
Contemporary European studies examining associations between socioeconomic status and hepatocellular carcinoma (HCC) incidence are scarce. We aimed to target population groups with a heavier burden of HCC by assessing associations of individual-level sociodemographic variables and neighbourhood deprivation with all-stage and stage-specific HCC incidence rates (IR). Patient and population data stratified by calendar year (2012-2018), sex, age (5-year groups), household income (low, medium, high), country of birth (Nordic, non-Nordic) and neighbourhood deprivation (national quintiles Q1-Q5) were retrieved from Swedish registers. HCC stages were defined by Barcelona Clinic Liver Cancer stages 0-A (early-stage) and B-D (late-stage). IR (per... (More)
Contemporary European studies examining associations between socioeconomic status and hepatocellular carcinoma (HCC) incidence are scarce. We aimed to target population groups with a heavier burden of HCC by assessing associations of individual-level sociodemographic variables and neighbourhood deprivation with all-stage and stage-specific HCC incidence rates (IR). Patient and population data stratified by calendar year (2012-2018), sex, age (5-year groups), household income (low, medium, high), country of birth (Nordic, non-Nordic) and neighbourhood deprivation (national quintiles Q1-Q5) were retrieved from Swedish registers. HCC stages were defined by Barcelona Clinic Liver Cancer stages 0-A (early-stage) and B-D (late-stage). IR (per 100 000 person-years) were estimated by Poisson regression models. Men had four times higher IR than women. IRs increased markedly with lower household income as well as with neighbourhood deprivation. Seven times higher IR was observed among people with a low household income living in the most deprived neighbourhoods (IR 3.90, 95% confidence interval [CI] 3.28-4.64) compared to people with a high household income living in the least deprived neighbourhoods (IR 0.58, 95% CI 0.46-0.74). The gradient across income categories was more pronounced for late-stage than early-stage HCC. IR reached 30 (per 100 000 person-years) for people in the age span 60-79 years with low income and 20 for 60-79 year old people living in the most deprived neighbourhoods (regardless of income). Men with low household income and/or living in the most deprived neighbourhoods might be considered as primary targets in studies evaluating the cost-effectiveness of screening for early-stage HCC detection. This article is protected by copyright. All rights reserved.
(Less)
- author
- Vaz, Juan
LU
; Midlöv, Patrik
LU
; Eilard, Malin Sternby
; Eriksson, Berne
; Buchebner, David
LU
and Strömberg, Ulf
LU
- organization
- publishing date
- 2022-03-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cancer
- volume
- 151
- issue
- 2
- pages
- 229 - 239
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85126065367
- pmid:35253900
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.33993
- language
- English
- LU publication?
- yes
- additional info
- This article is protected by copyright. All rights reserved.
- id
- 7c209f82-9b9a-4192-8eb0-e2ca930bfe8d
- date added to LUP
- 2022-03-13 06:57:14
- date last changed
- 2024-06-20 18:57:29
@article{7c209f82-9b9a-4192-8eb0-e2ca930bfe8d,
abstract = {{<p>Contemporary European studies examining associations between socioeconomic status and hepatocellular carcinoma (HCC) incidence are scarce. We aimed to target population groups with a heavier burden of HCC by assessing associations of individual-level sociodemographic variables and neighbourhood deprivation with all-stage and stage-specific HCC incidence rates (IR). Patient and population data stratified by calendar year (2012-2018), sex, age (5-year groups), household income (low, medium, high), country of birth (Nordic, non-Nordic) and neighbourhood deprivation (national quintiles Q1-Q5) were retrieved from Swedish registers. HCC stages were defined by Barcelona Clinic Liver Cancer stages 0-A (early-stage) and B-D (late-stage). IR (per 100 000 person-years) were estimated by Poisson regression models. Men had four times higher IR than women. IRs increased markedly with lower household income as well as with neighbourhood deprivation. Seven times higher IR was observed among people with a low household income living in the most deprived neighbourhoods (IR 3.90, 95% confidence interval [CI] 3.28-4.64) compared to people with a high household income living in the least deprived neighbourhoods (IR 0.58, 95% CI 0.46-0.74). The gradient across income categories was more pronounced for late-stage than early-stage HCC. IR reached 30 (per 100 000 person-years) for people in the age span 60-79 years with low income and 20 for 60-79 year old people living in the most deprived neighbourhoods (regardless of income). Men with low household income and/or living in the most deprived neighbourhoods might be considered as primary targets in studies evaluating the cost-effectiveness of screening for early-stage HCC detection. This article is protected by copyright. All rights reserved.</p>}},
author = {{Vaz, Juan and Midlöv, Patrik and Eilard, Malin Sternby and Eriksson, Berne and Buchebner, David and Strömberg, Ulf}},
issn = {{0020-7136}},
language = {{eng}},
month = {{03}},
number = {{2}},
pages = {{229--239}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Targeting population groups with heavier burden of hepatocellular carcinoma incidence : a nationwide descriptive epidemiological study in Sweden}},
url = {{http://dx.doi.org/10.1002/ijc.33993}},
doi = {{10.1002/ijc.33993}},
volume = {{151}},
year = {{2022}},
}