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Male Infertility and Risk of Nonmalignant Chronic Diseases : A Systematic Review of the Epidemiological Evidence

Glazer, Clara Helene; Bonde, Jens-Peter; Eisenberg, Michael L.; Giwercman, Aleksander LU ; Hærvig, Katia Keglberg; Rimborg, Susie; Vassard, Ditte; Pinborg, Anja; Schmidt, Lone and Bräuner, Elvira Vaclavik (2017) In Seminars in Reproductive Medicine 35(3). p.282-290
Abstract

The association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The... (More)

The association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic diseases, comorbidity, male infertility, mortality
in
Seminars in Reproductive Medicine
volume
35
issue
3
pages
9 pages
external identifiers
  • scopus:85021640556
  • wos:000404529800012
ISSN
1526-8004
DOI
10.1055/s-0037-1603568
language
English
LU publication?
yes
id
7c22109f-61a5-408b-bf50-da0d6f7f8ab1
date added to LUP
2017-08-21 11:03:08
date last changed
2017-09-18 11:42:15
@article{7c22109f-61a5-408b-bf50-da0d6f7f8ab1,
  abstract     = {<p>The association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.</p>},
  author       = {Glazer, Clara Helene and Bonde, Jens-Peter and Eisenberg, Michael L. and Giwercman, Aleksander and Hærvig, Katia Keglberg and Rimborg, Susie and Vassard, Ditte and Pinborg, Anja and Schmidt, Lone and Bräuner, Elvira Vaclavik},
  issn         = {1526-8004},
  keyword      = {chronic diseases,comorbidity,male infertility,mortality},
  language     = {eng},
  month        = {05},
  number       = {3},
  pages        = {282--290},
  series       = {Seminars in Reproductive Medicine},
  title        = {Male Infertility and Risk of Nonmalignant Chronic Diseases : A Systematic Review of the Epidemiological Evidence},
  url          = {http://dx.doi.org/10.1055/s-0037-1603568},
  volume       = {35},
  year         = {2017},
}