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With increasing age at tumor diagnosis in families with cancer, cancer is limited to fewer organs

H.L., Olsson LU (2016) American Association for Cancer Research (AACR) 107th Annual Meeting 2016 In Cancer Research 76(14 Suppl).
Abstract
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that very late in life, only a few organs are affected by tumours disease. The reason for this could be that the tumour originates from a more differentiated, organ-specific progenitor/stem cell later in life, while the progenitor/stem cell might be involved in organogenesis in different organs earlier in life. Examples are given for skin cancer and... (More)
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that very late in life, only a few organs are affected by tumours disease. The reason for this could be that the tumour originates from a more differentiated, organ-specific progenitor/stem cell later in life, while the progenitor/stem cell might be involved in organogenesis in different organs earlier in life. Examples are given for skin cancer and breast cancer. Summary: Patients with familial cancer who present with cancer at an older age at tumour presentation have a more organ restricted disease. This could be because the tumor has a more differentiated progenitor/stem cell origin. Examples are given for families with breast cancer, melanoma, and non-melanoma skin cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, cancer epidemiology, cancer patient, clinical study, diagnosis, hereditary tumor syndrome, female, genetic predisposition, human, melanoma, organogenesis, skin cancer, stem cell, tumor diagnosis, twin study
in
Cancer Research
volume
76
issue
14 Suppl
publisher
American Association for Cancer Research Inc.
conference name
American Association for Cancer Research (AACR) 107th Annual Meeting 2016
conference location
New Orleans, United States
conference dates
2016-04-16 - 2016-04-20
ISSN
1538-7445
DOI
10.1158/1538-7445.AM2016-2546
language
English
LU publication?
yes
id
7c9af205-c84d-4abc-bb7d-ec69657fffea
date added to LUP
2019-07-01 10:53:22
date last changed
2019-07-01 10:53:22
@misc{7c9af205-c84d-4abc-bb7d-ec69657fffea,
  abstract     = {Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that very late in life, only a few organs are affected by tumours disease. The reason for this could be that the tumour originates from a more differentiated, organ-specific progenitor/stem cell later in life, while the progenitor/stem cell might be involved in organogenesis in different organs earlier in life. Examples are given for skin cancer and breast cancer. Summary: Patients with familial cancer who present with cancer at an older age at tumour presentation have a more organ restricted disease. This could be because the tumor has a more differentiated progenitor/stem cell origin. Examples are given for families with breast cancer, melanoma, and non-melanoma skin cancer.},
  articleno    = {Abstract 2546},
  author       = {H.L., Olsson},
  issn         = {1538-7445},
  keyword      = {breast cancer,cancer epidemiology,cancer patient,clinical study,diagnosis,hereditary tumor syndrome,female,genetic predisposition,human,melanoma,organogenesis,skin cancer,stem cell,tumor diagnosis,twin study},
  language     = {eng},
  location     = {New Orleans, United States},
  note         = {Conference Abstract},
  number       = {14 Suppl},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {With increasing age at tumor diagnosis in families with cancer, cancer is limited to fewer organs},
  url          = {http://dx.doi.org/10.1158/1538-7445.AM2016-2546},
  volume       = {76},
  year         = {2016},
}