Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.
(2015) In Journal of Clinical Oncology 33(24). p.81-2632- Abstract
- In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7749726
- author
- organization
-
- Tumor microenvironment (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Hypertension (research group)
- Diabetes - Cardiovascular Disease (research group)
- Surgery (research group)
- Translational Muscle Research (research group)
- Internal Medicine - Epidemiology (research group)
- Cardiovascular Research - Epidemiology (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Breastcancer-genetics
- Tumor microenvironment
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Oncology
- volume
- 33
- issue
- 24
- pages
- 81 - 2632
- publisher
- American Society of Clinical Oncology
- external identifiers
-
- pmid:26169618
- wos:000361655000011
- scopus:84940521359
- pmid:26169618
- ISSN
- 1527-7755
- DOI
- 10.1200/JCO.2014.59.7682
- language
- English
- LU publication?
- yes
- id
- 7caf07cb-8d75-46fa-8423-3c3b586ad19c (old id 7749726)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26169618?dopt=Abstract
- date added to LUP
- 2016-04-01 10:39:40
- date last changed
- 2024-03-13 10:24:14
@article{7caf07cb-8d75-46fa-8423-3c3b586ad19c, abstract = {{In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.}}, author = {{Melander, Olle and Orho-Melander, Marju and Manjer, Jonas and Svensson, Thomas and Almgren, Peter and Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Borgquist, Signe and Hartmann, Oliver and Struck, Joachim and Bergmann, Andreas and Belting, Mattias}}, issn = {{1527-7755}}, language = {{eng}}, number = {{24}}, pages = {{81--2632}}, publisher = {{American Society of Clinical Oncology}}, series = {{Journal of Clinical Oncology}}, title = {{Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.}}, url = {{http://dx.doi.org/10.1200/JCO.2014.59.7682}}, doi = {{10.1200/JCO.2014.59.7682}}, volume = {{33}}, year = {{2015}}, }