Survival and causes of death in adults with spina bifida in Sweden : a population-based case-control study
Rocchi, Melinda ; Jarl, Johan LU
; Lundkvist Josenby, Annika
LU
and Alriksson-Schmidt, Ann I
LU
(2023)
In Journal of Rehabilitation Medicine
55.
- Abstract
OBJECTIVE: To analyse survival rates and causes of death in adults with spina bifida in Sweden compared with a matched control group.
DESIGN AND METHODS: This population-based study included 11,900 adults born between 1950 and 1997. Three national Swedish registers were used to identify individuals with a diagnosis of spina bifida and a matched control group without spina bifida in the period 1990-2015. International Classification of Diseases codes were used to identify causes of death. Survival analysis was conducted and causes of death in the 2 groups were compared.
RESULTS: There was a lower probability of survival for people with spina bifida in all age groups (p < 0.001) compared with the control group. The most... (More)
OBJECTIVE: To analyse survival rates and causes of death in adults with spina bifida in Sweden compared with a matched control group.
DESIGN AND METHODS: This population-based study included 11,900 adults born between 1950 and 1997. Three national Swedish registers were used to identify individuals with a diagnosis of spina bifida and a matched control group without spina bifida in the period 1990-2015. International Classification of Diseases codes were used to identify causes of death. Survival analysis was conducted and causes of death in the 2 groups were compared.
RESULTS: There was a lower probability of survival for people with spina bifida in all age groups (p < 0.001) compared with the control group. The most prevalent causes of death in people with spina bifida were congenital, respiratory, nervous, cardiovascular, genitourinary, and injuries. People with spina bifida had a higher probability of dying from congenital (p < 0.001), respiratory (p = 0.002), genitourinary (p < 0.002), and nervous-related (p < 0.001) and lower probability of injury-related deaths (p < 0.001).
CONCLUSION: Adults with spina bifida in Sweden have a lower survival rate compared with the general population, with the frequency of certain causes of death differing between the two groups. In order to reduce excess premature mortality, prevention and careful management of potentially fatal conditions are essential throughout a patient's lifespan.
(Less)
- author
- Rocchi, Melinda
; Jarl, Johan
LU
; Lundkvist Josenby, Annika
LU
and Alriksson-Schmidt, Ann I
LU
- organization
- publishing date
- 2023-11-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Adult, Sweden/epidemiology, Case-Control Studies, Cause of Death, Spinal Dysraphism, Research Design, spina bifida, transition to adult care, adults, mortality, survival
- in
- Journal of Rehabilitation Medicine
- volume
- 55
- article number
- jrm18244
- pages
- 8 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85180861584
- pmid:38010218
- ISSN
- 1651-2081
- DOI
- 10.2340/jrm.v55.18244
- language
- English
- LU publication?
- yes
- id
- 7cb32b25-8458-4e10-ba7b-994b66616d2e
- date added to LUP
- 2023-11-29 14:10:47
- date last changed
- 2024-04-14 19:32:20
@article{7cb32b25-8458-4e10-ba7b-994b66616d2e,
abstract = {{<p>OBJECTIVE: To analyse survival rates and causes of death in adults with spina bifida in Sweden compared with a matched control group.</p><p>DESIGN AND METHODS: This population-based study included 11,900 adults born between 1950 and 1997. Three national Swedish registers were used to identify individuals with a diagnosis of spina bifida and a matched control group without spina bifida in the period 1990-2015. International Classification of Diseases codes were used to identify causes of death. Survival analysis was conducted and causes of death in the 2 groups were compared.</p><p>RESULTS: There was a lower probability of survival for people with spina bifida in all age groups (p < 0.001) compared with the control group. The most prevalent causes of death in people with spina bifida were congenital, respiratory, nervous, cardiovascular, genitourinary, and injuries. People with spina bifida had a higher probability of dying from congenital (p < 0.001), respiratory (p = 0.002), genitourinary (p < 0.002), and nervous-related (p < 0.001) and lower probability of injury-related deaths (p < 0.001).</p><p>CONCLUSION: Adults with spina bifida in Sweden have a lower survival rate compared with the general population, with the frequency of certain causes of death differing between the two groups. In order to reduce excess premature mortality, prevention and careful management of potentially fatal conditions are essential throughout a patient's lifespan.</p>}},
author = {{Rocchi, Melinda and Jarl, Johan and Lundkvist Josenby, Annika and Alriksson-Schmidt, Ann I}},
issn = {{1651-2081}},
keywords = {{Humans; Adult; Sweden/epidemiology; Case-Control Studies; Cause of Death; Spinal Dysraphism; Research Design; spina bifida; transition to adult care; adults; mortality; survival}},
language = {{eng}},
month = {{11}},
publisher = {{Taylor & Francis}},
series = {{Journal of Rehabilitation Medicine}},
title = {{Survival and causes of death in adults with spina bifida in Sweden : a population-based case-control study}},
url = {{http://dx.doi.org/10.2340/jrm.v55.18244}},
doi = {{10.2340/jrm.v55.18244}},
volume = {{55}},
year = {{2023}},
}