How to assess transport in animals?
(2009) 12th Congress of the International-Society-for-Peritoneal-Dialysis In Peritoneal Dialysis International 29(Suppl. 2). p.32-35- Abstract
- The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different... (More)
- The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1370650
- author
- Rippe, Bengt LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Capillary permeability, rat, aquaporin-1, transcytosis, mouse
- in
- Peritoneal Dialysis International
- volume
- 29
- issue
- Suppl. 2
- pages
- 32 - 35
- publisher
- Multimed Inc.
- conference name
- 12th Congress of the International-Society-for-Peritoneal-Dialysis
- conference dates
- 2008-06-20 - 2008-06-24
- external identifiers
-
- wos:000263937100005
- pmid:19270227
- scopus:67449094663
- ISSN
- 1718-4304
- language
- English
- LU publication?
- yes
- id
- 7cc9523b-e3a7-4e40-a79e-7c77456f219a (old id 1370650)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19270227?dopt=Abstract
- date added to LUP
- 2016-04-01 12:55:37
- date last changed
- 2022-02-21 19:19:53
@article{7cc9523b-e3a7-4e40-a79e-7c77456f219a,
abstract = {{The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis.}},
author = {{Rippe, Bengt}},
issn = {{1718-4304}},
keywords = {{Capillary permeability; rat; aquaporin-1; transcytosis; mouse}},
language = {{eng}},
number = {{Suppl. 2}},
pages = {{32--35}},
publisher = {{Multimed Inc.}},
series = {{Peritoneal Dialysis International}},
title = {{How to assess transport in animals?}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/19270227?dopt=Abstract}},
volume = {{29}},
year = {{2009}},
}