Two allotypes of factor IX present in haemophilia B
(1986) In Scandinavian Journal of Haematology 37(5). p.411-416- Abstract
Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.
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https://lup.lub.lu.se/record/7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef
- author
- Ljung, R. LU ; Wallmark, A. LU and Nilsson, Inga Marie
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- in
- Scandinavian Journal of Haematology
- volume
- 37
- issue
- 5
- pages
- 411 - 416
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0022862160
- pmid:3810038
- ISSN
- 0036-553X
- DOI
- 10.1111/j.1600-0609.1986.tb02629.x
- language
- English
- LU publication?
- yes
- id
- 7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef
- date added to LUP
- 2016-10-26 13:54:58
- date last changed
- 2024-01-04 14:59:24
@article{7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef, abstract = {{<p>Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.</p>}}, author = {{Ljung, R. and Wallmark, A. and Nilsson, Inga Marie}}, issn = {{0036-553X}}, language = {{eng}}, number = {{5}}, pages = {{411--416}}, publisher = {{Wiley-Blackwell}}, series = {{Scandinavian Journal of Haematology}}, title = {{Two allotypes of factor IX present in haemophilia B}}, url = {{http://dx.doi.org/10.1111/j.1600-0609.1986.tb02629.x}}, doi = {{10.1111/j.1600-0609.1986.tb02629.x}}, volume = {{37}}, year = {{1986}}, }