Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses : A Multicenter Study Using Intracoronary Pressure and Flow
(2019) In Circulation. Cardiovascular Interventions 12(12).- Abstract
BACKGROUND: Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the aortic valve and the coronary disease influence the blood flow to the myocardium and its ability to respond to stress; leading to exertional symptoms. In this study, we aim to quantify the effect of severe AS on the coronary microcirculation and determine if this is influenced by any concomitant coronary disease. We then compare this to the effect of coronary stenoses on the coronary microcirculation. METHODS: Group 1: 55 patients with severe AS and intermediate coronary stenoses treated with transcatheter aortic valve implantation (TAVI) were included. Group 2: 85 patients with intermediate coronary stenoses and no AS treated with... (More)
BACKGROUND: Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the aortic valve and the coronary disease influence the blood flow to the myocardium and its ability to respond to stress; leading to exertional symptoms. In this study, we aim to quantify the effect of severe AS on the coronary microcirculation and determine if this is influenced by any concomitant coronary disease. We then compare this to the effect of coronary stenoses on the coronary microcirculation. METHODS: Group 1: 55 patients with severe AS and intermediate coronary stenoses treated with transcatheter aortic valve implantation (TAVI) were included. Group 2: 85 patients with intermediate coronary stenoses and no AS treated with percutaneous coronary intervention were included. Coronary pressure and flow were measured at rest and during hyperemia in both groups, before and after TAVI (group 1) and before and after percutaneous coronary intervention (group 2). RESULTS: Microvascular resistance over the wave-free period of diastole increased significantly post-TAVI (pre-TAVI, 2.71±1.4 mm Hg·cm·s-1 versus post-TAVI 3.04±1.6 mm Hg·cm·s-1 [P=0.03]). Microvascular reserve over the wave-free period of diastole significantly improved post-TAVI (pre-TAVI 1.88±1.0 versus post-TAVI 2.09±0.8 [P=0.003]); this was independent of the severity of the underlying coronary stenosis. The change in microvascular resistance post-TAVI was equivalent to that produced by stenting a coronary lesion with an instantaneous wave-free ratio of ≤0.74. CONCLUSIONS: TAVI improves microcirculatory function regardless of the severity of underlying coronary disease. TAVI for severe AS produces a coronary hemodynamic improvement equivalent to the hemodynamic benefit of stenting coronary stenoses with instantaneous wave-free ratio values <0.74. Future trials of physiology-guided revascularization in severe AS may consider using this value to guide treatment of concomitant coronary artery disease.
(Less)
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aortic valve stenosis, diastole, hyperemia, microcirculation, myocardium
- in
- Circulation. Cardiovascular Interventions
- volume
- 12
- issue
- 12
- article number
- e008263
- publisher
- American Heart Association
- external identifiers
-
- pmid:31752515
- scopus:85075494229
- ISSN
- 1941-7632
- DOI
- 10.1161/CIRCINTERVENTIONS.119.008263
- language
- English
- LU publication?
- yes
- id
- 7d239867-1368-4d7a-bd5c-97fd986acca7
- date added to LUP
- 2019-12-04 14:08:32
- date last changed
- 2024-04-02 22:28:19
@article{7d239867-1368-4d7a-bd5c-97fd986acca7, abstract = {{<p>BACKGROUND: Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the aortic valve and the coronary disease influence the blood flow to the myocardium and its ability to respond to stress; leading to exertional symptoms. In this study, we aim to quantify the effect of severe AS on the coronary microcirculation and determine if this is influenced by any concomitant coronary disease. We then compare this to the effect of coronary stenoses on the coronary microcirculation. METHODS: Group 1: 55 patients with severe AS and intermediate coronary stenoses treated with transcatheter aortic valve implantation (TAVI) were included. Group 2: 85 patients with intermediate coronary stenoses and no AS treated with percutaneous coronary intervention were included. Coronary pressure and flow were measured at rest and during hyperemia in both groups, before and after TAVI (group 1) and before and after percutaneous coronary intervention (group 2). RESULTS: Microvascular resistance over the wave-free period of diastole increased significantly post-TAVI (pre-TAVI, 2.71±1.4 mm Hg·cm·s-1 versus post-TAVI 3.04±1.6 mm Hg·cm·s-1 [P=0.03]). Microvascular reserve over the wave-free period of diastole significantly improved post-TAVI (pre-TAVI 1.88±1.0 versus post-TAVI 2.09±0.8 [P=0.003]); this was independent of the severity of the underlying coronary stenosis. The change in microvascular resistance post-TAVI was equivalent to that produced by stenting a coronary lesion with an instantaneous wave-free ratio of ≤0.74. CONCLUSIONS: TAVI improves microcirculatory function regardless of the severity of underlying coronary disease. TAVI for severe AS produces a coronary hemodynamic improvement equivalent to the hemodynamic benefit of stenting coronary stenoses with instantaneous wave-free ratio values <0.74. Future trials of physiology-guided revascularization in severe AS may consider using this value to guide treatment of concomitant coronary artery disease.</p>}}, author = {{Ahmad, Yousif and Vendrik, Jeroen and Eftekhari, Ashkan and Howard, James P. and Cook, Christopher and Rajkumar, Christopher and Malik, Iqbal and Mikhail, Ghada and Ruparelia, Neil and Hadjiloizou, Nearchos and Nijjer, Sukhjinder and Al-Lamee, Rasha and Petraco, Ricardo and Warisawa, Takayuki and Wijntjens, Gilbert W.M. and Koch, Karel T. and van de Hoef, Tim and de Waard, Guus and Echavarria-Pinto, Mauro and Frame, Angela and Sutaria, Nilesh and Kanaganayagam, Gajen and Ariff, Ben and Anderson, Jon and Chukwuemeka, Andrew and Fertleman, Michael and Koul, Sasha and Iglesias, Juan F. and Francis, Darrel and Mayet, Jamil and Serruys, Patrick and Davies, Justin and Escaned, Javier and van Royen, Niels and Götberg, Matthias and Juhl Terkelsen, Christian and Høj Christiansen, Evald and Piek, Jan J. and Baan, Jan and Sen, Sayan}}, issn = {{1941-7632}}, keywords = {{aortic valve stenosis; diastole; hyperemia; microcirculation; myocardium}}, language = {{eng}}, number = {{12}}, publisher = {{American Heart Association}}, series = {{Circulation. Cardiovascular Interventions}}, title = {{Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses : A Multicenter Study Using Intracoronary Pressure and Flow}}, url = {{http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008263}}, doi = {{10.1161/CIRCINTERVENTIONS.119.008263}}, volume = {{12}}, year = {{2019}}, }