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Pulmonary blood volume indexed to lung volume is reduced in newly diagnosed systemic sclerosis compared to normals - a prospective clinical cardiovascular magnetic resonance study addressing pulmonary vascular changes

Kanski, Mikael LU ; Arheden, Håkan LU ; Wuttge, Dirk LU ; Bozovic, Gracijela LU ; Hesselstrand, Roger LU and Ugander, Martin LU (2013) In Journal of Cardiovascular Magnetic Resonance 15.
Abstract
Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-seven SSc patients (9 men, 57 +/- 13 years) and 10 healthy controls (3 men, 54 +/- 9 years) underwent CMR to determine the pulmonary blood volume (PBV) and the PBV variation (PBVV) throughout the cardiac cycle. Patients underwent Doppler echocardiography, high-resolution computed tomography (HRCT), and pulmonary function testing by spirometry.... (More)
Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-seven SSc patients (9 men, 57 +/- 13 years) and 10 healthy controls (3 men, 54 +/- 9 years) underwent CMR to determine the pulmonary blood volume (PBV) and the PBV variation (PBVV) throughout the cardiac cycle. Patients underwent Doppler echocardiography, high-resolution computed tomography (HRCT), and pulmonary function testing by spirometry. Comparisons were performed using the unpaired t-test and linear regression analysis was performed with Pearson's correlation coefficient (r). Results: Compared to healthy controls, the PBV indexed to lung volume (PBVI) was lower in patients (16 +/- 4 vs 20 +/- 5%, p < 0.05). There was no difference in PBV (466 +/- 87 vs 471 +/- 122 mL, p = 0.91) or PBVV/stroke volume (45 +/- 10 vs 40 +/- 6%, p = 0.09). There were no significant correlations between PBVI and pulmonary artery pressure estimated by Doppler (p = 0.08) the lung's diffusion capacity for carbon monoxide (DLCO) (p = 0.09), vital capacity (p = 0.45), or pulmonary fibrosis by HRCT (p = 0.74). Conclusions: This study is the first to measure the PBV in humans using CMR. Compared to healthy controls, newly diagnosed SSc patients have a reduced amount of blood in the pulmonary vasculature (PBVI) but unchanged pulmonary vascular distensibility (PBVV/stroke volume). PBVI is unrelated to DLCO, pulmonary artery pressure, vital capacity, and the presence of pulmonary fibrosis. PBVI may be a novel parameter reflecting vascular lung involvement in early-stage SSc, and these findings may be consistent with pathophysiological changes of the pulmonary vasculature. (Less)
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; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiovascular Magnetic Resonance
volume
15
article number
86
publisher
BioMed Central (BMC)
external identifiers
  • wos:000325248900001
  • scopus:84884581304
  • pmid:24066703
ISSN
1097-6647
DOI
10.1186/1532-429X-15-86
language
English
LU publication?
yes
id
7d72cc01-89d0-44f6-bb3f-d7e5a4505d35 (old id 4172192)
date added to LUP
2016-04-01 11:14:40
date last changed
2022-02-10 17:51:10
@article{7d72cc01-89d0-44f6-bb3f-d7e5a4505d35,
  abstract     = {{Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-seven SSc patients (9 men, 57 +/- 13 years) and 10 healthy controls (3 men, 54 +/- 9 years) underwent CMR to determine the pulmonary blood volume (PBV) and the PBV variation (PBVV) throughout the cardiac cycle. Patients underwent Doppler echocardiography, high-resolution computed tomography (HRCT), and pulmonary function testing by spirometry. Comparisons were performed using the unpaired t-test and linear regression analysis was performed with Pearson's correlation coefficient (r). Results: Compared to healthy controls, the PBV indexed to lung volume (PBVI) was lower in patients (16 +/- 4 vs 20 +/- 5%, p &lt; 0.05). There was no difference in PBV (466 +/- 87 vs 471 +/- 122 mL, p = 0.91) or PBVV/stroke volume (45 +/- 10 vs 40 +/- 6%, p = 0.09). There were no significant correlations between PBVI and pulmonary artery pressure estimated by Doppler (p = 0.08) the lung's diffusion capacity for carbon monoxide (DLCO) (p = 0.09), vital capacity (p = 0.45), or pulmonary fibrosis by HRCT (p = 0.74). Conclusions: This study is the first to measure the PBV in humans using CMR. Compared to healthy controls, newly diagnosed SSc patients have a reduced amount of blood in the pulmonary vasculature (PBVI) but unchanged pulmonary vascular distensibility (PBVV/stroke volume). PBVI is unrelated to DLCO, pulmonary artery pressure, vital capacity, and the presence of pulmonary fibrosis. PBVI may be a novel parameter reflecting vascular lung involvement in early-stage SSc, and these findings may be consistent with pathophysiological changes of the pulmonary vasculature.}},
  author       = {{Kanski, Mikael and Arheden, Håkan and Wuttge, Dirk and Bozovic, Gracijela and Hesselstrand, Roger and Ugander, Martin}},
  issn         = {{1097-6647}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Cardiovascular Magnetic Resonance}},
  title        = {{Pulmonary blood volume indexed to lung volume is reduced in newly diagnosed systemic sclerosis compared to normals - a prospective clinical cardiovascular magnetic resonance study addressing pulmonary vascular changes}},
  url          = {{https://lup.lub.lu.se/search/files/2502177/4431957.pdf}},
  doi          = {{10.1186/1532-429X-15-86}},
  volume       = {{15}},
  year         = {{2013}},
}