Advanced

Why Do Sex Chromosomes Stop Recombining?

Ponnikas, Suvi LU ; Sigeman, Hanna LU ; Abbott, Jessica K. LU and Hansson, Bengt LU (2018) In Trends in Genetics
Abstract

It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including... (More)

It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
heterozygote advantage, meiotic drive, recombination suppression, sex chromosome, sex determination, sexual antagonism
in
Trends in Genetics
publisher
Elsevier
external identifiers
  • scopus:85046168465
ISSN
0168-9525
DOI
10.1016/j.tig.2018.04.001
language
English
LU publication?
yes
id
7ddedc60-1598-42d4-a3b8-ce7839981d16
date added to LUP
2018-05-15 14:09:39
date last changed
2018-08-12 04:44:02
@article{7ddedc60-1598-42d4-a3b8-ce7839981d16,
  abstract     = {<p>It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.</p>},
  author       = {Ponnikas, Suvi and Sigeman, Hanna and Abbott, Jessica K. and Hansson, Bengt},
  issn         = {0168-9525},
  keyword      = {heterozygote advantage,meiotic drive,recombination suppression,sex chromosome,sex determination,sexual antagonism},
  language     = {eng},
  month        = {04},
  publisher    = {Elsevier},
  series       = {Trends in Genetics},
  title        = {Why Do Sex Chromosomes Stop Recombining?},
  url          = {http://dx.doi.org/10.1016/j.tig.2018.04.001},
  year         = {2018},
}