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Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC)

Rohrmann, Sabine ; Linseisen, Jakob ; Boshuizen, Hendriek C. ; Whittaker, John ; Agudo, Antonio ; Vineis, Paolo ; Boffetta, Paolo ; Jensen, Majken K. ; Olsen, Anja and Overvad, Kim , et al. (2006) In American Journal of Epidemiology 164(11). p.1103-1114
Abstract
Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95%... (More)
Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (>= 60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption. (Less)
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publication status
published
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keywords
lung neoplasms, cohort studies, ethanol, alcohol drinking
in
American Journal of Epidemiology
volume
164
issue
11
pages
1103 - 1114
publisher
Oxford University Press
external identifiers
  • wos:000242245000009
  • scopus:33845193649
ISSN
0002-9262
DOI
10.1093/aje/kwj326
language
English
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yes
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7e5792ea-da50-4476-ba45-71cbe3ec0d7b (old id 376695)
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2016-04-01 12:38:37
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2019-11-13 02:15:24
@article{7e5792ea-da50-4476-ba45-71cbe3ec0d7b,
  abstract     = {Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (>= 60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Boshuizen, Hendriek C. and Whittaker, John and Agudo, Antonio and Vineis, Paolo and Boffetta, Paolo and Jensen, Majken K. and Olsen, Anja and Overvad, Kim and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Bergmann, Manuela M. and Boeing, Heiner and Allen, Naomi and Key, Tim and Bingham, Sheila and Khaw, Kay-Tee and Kyriazi, Georgia and Soukara, Stavroula and Trichopoulou, Antonia and Panico, Salvatore and Palli, Domenico and Sieri, Sabina and Tumino, Rosario and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and Buchner, Frederike L. and Gram, Inger Torhild and Lund, Eiliv and Ardanaz, Eva and Chirlaque, Maria-Dolores and Dorronsoro, Miren and Sanchez Perez, Maria-Jose and Quiros, Jose R. and Berglund, Göran and Janzon, Lars and Rasmuson, Torgny and Weinehall, Lars and Ferrari, Pietro and Jenab, Mazda and Norat, Teresa and Riboli, Elio},
  issn         = {0002-9262},
  language     = {eng},
  number       = {11},
  pages        = {1103--1114},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1093/aje/kwj326},
  doi          = {10.1093/aje/kwj326},
  volume       = {164},
  year         = {2006},
}