Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases
(2015) In Future science OA 1(4).- Abstract
AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.
MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.
RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to... (More)
AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.
MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.
RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.
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- author
- Kjellman, Pontus LU ; Fredriksson, Sarah LU ; Kjellman, Christian LU ; Strand, Sven-Erik LU and Zandt, René In 't LU
- organization
- publishing date
- 2015-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Future science OA
- volume
- 1
- issue
- 4
- article number
- FSO60
- publisher
- Future Medicine Ltd.
- external identifiers
-
- pmid:28031912
- wos:000218437300011
- scopus:85037669808
- ISSN
- 2056-5623
- DOI
- 10.4155/fso.15.60
- language
- English
- LU publication?
- yes
- id
- 7e88a85b-851b-46e9-8ddb-00b1f3a32b87
- date added to LUP
- 2017-02-13 14:20:55
- date last changed
- 2024-07-07 11:29:30
@article{7e88a85b-851b-46e9-8ddb-00b1f3a32b87, abstract = {{<p>AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.</p><p>MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.</p><p>RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.</p>}}, author = {{Kjellman, Pontus and Fredriksson, Sarah and Kjellman, Christian and Strand, Sven-Erik and Zandt, René In 't}}, issn = {{2056-5623}}, language = {{eng}}, number = {{4}}, publisher = {{Future Medicine Ltd.}}, series = {{Future science OA}}, title = {{Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases}}, url = {{http://dx.doi.org/10.4155/fso.15.60}}, doi = {{10.4155/fso.15.60}}, volume = {{1}}, year = {{2015}}, }