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Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases

Kjellman, Pontus LU ; Fredriksson, Sarah LU ; Kjellman, Christian LU ; Strand, Sven-Erik LU and Zandt, René In 't LU (2015) In Future science OA 1(4).
Abstract

AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.

MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.

RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to... (More)

AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.

MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.

RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.

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type
Contribution to journal
publication status
published
subject
in
Future science OA
volume
1
issue
4
ISSN
2056-5623
DOI
10.4155/fso.15.60
language
English
LU publication?
yes
id
7e88a85b-851b-46e9-8ddb-00b1f3a32b87
date added to LUP
2017-02-13 14:20:55
date last changed
2017-11-16 13:00:50
@article{7e88a85b-851b-46e9-8ddb-00b1f3a32b87,
  abstract     = {<p>AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.</p><p>MATERIALS &amp; METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.</p><p>RESULTS &amp; CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.</p>},
  articleno    = {FSO60},
  author       = {Kjellman, Pontus and Fredriksson, Sarah and Kjellman, Christian and Strand, Sven-Erik and Zandt, René In 't},
  issn         = {2056-5623},
  language     = {eng},
  number       = {4},
  series       = {Future science OA},
  title        = {Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases},
  url          = {http://dx.doi.org/10.4155/fso.15.60},
  volume       = {1},
  year         = {2015},
}