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High Familial Risk of Atrial Fibrillation/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden

Zöller, Bengt LU ; Ohlsson, Henrik LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2013) In Journal of the American Heart Association 2(1). p.003384-003384
Abstract
Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases... (More)
Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [OR] 1.95 [95% CI 1.89 to 2.00]) and siblings (OR=3.08 [3.00 to 3.16]) of cases had higher odds of AF/AFl than did parents and siblings of controls. AF/AFl ORs were increased in both sexes. For 2% of cases, both parents had AF/AFl, compared with only 0.7% of controls (OR= 3.60 [3.30 to 3.92]). Moreover, 3% of cases had >= 2 siblings with AF/AFl, compared with 1% of controls (OR= 5.72 [5.28 to 6.19]). In premature cases (diagnosed at age < 50 years), the ORs were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for AF/AFl in both parents and AF/AFl in >= 2 siblings, respectively. The overall spouse OR was 1.16 (1.13 to 1.19). Conclusions-Family history of AF/AFl increases the odds of AF/AFl in first-degree relatives. High familial risks were observed in multiplex families. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrial fibrillation, atrial flutter, family history, risk factors, genetics
in
Journal of the American Heart Association
volume
2
issue
1
pages
003384 - 003384
publisher
Wiley-Blackwell
external identifiers
  • wos:000326336800042
  • scopus:84884175582
  • pmid:23525409
ISSN
2047-9980
DOI
10.1161/JAHA.112.003384
language
English
LU publication?
yes
id
7e987b48-62dc-4fc8-89cb-ada1fff5677e (old id 4212466)
date added to LUP
2016-04-01 13:41:06
date last changed
2019-11-20 02:45:59
@article{7e987b48-62dc-4fc8-89cb-ada1fff5677e,
  abstract     = {Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [OR] 1.95 [95% CI 1.89 to 2.00]) and siblings (OR=3.08 [3.00 to 3.16]) of cases had higher odds of AF/AFl than did parents and siblings of controls. AF/AFl ORs were increased in both sexes. For 2% of cases, both parents had AF/AFl, compared with only 0.7% of controls (OR= 3.60 [3.30 to 3.92]). Moreover, 3% of cases had &gt;= 2 siblings with AF/AFl, compared with 1% of controls (OR= 5.72 [5.28 to 6.19]). In premature cases (diagnosed at age &lt; 50 years), the ORs were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for AF/AFl in both parents and AF/AFl in &gt;= 2 siblings, respectively. The overall spouse OR was 1.16 (1.13 to 1.19). Conclusions-Family history of AF/AFl increases the odds of AF/AFl in first-degree relatives. High familial risks were observed in multiplex families.},
  author       = {Zöller, Bengt and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina},
  issn         = {2047-9980},
  language     = {eng},
  number       = {1},
  pages        = {003384--003384},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the American Heart Association},
  title        = {High Familial Risk of Atrial Fibrillation/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden},
  url          = {http://dx.doi.org/10.1161/JAHA.112.003384},
  doi          = {10.1161/JAHA.112.003384},
  volume       = {2},
  year         = {2013},
}