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Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications

Engström, Gunnar LU ; Lampa, Erik ; Dekkers, Koen ; Lin, Yi Ting ; Ahlm, Kristin ; Ahlström, Håkan ; Alfredsson, Joakim ; Bergström, Göran ; Blomberg, Anders and Brandberg, John , et al. (2024) In European Journal of Epidemiology 39(1). p.35-49
Abstract

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa,... (More)

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Coronary heart disease, Emphysema, Spirometry
in
European Journal of Epidemiology
volume
39
issue
1
pages
15 pages
publisher
Springer
external identifiers
  • pmid:38165527
  • scopus:85181226926
ISSN
0393-2990
DOI
10.1007/s10654-023-01088-z
language
English
LU publication?
yes
id
7ea59b9b-a101-4c2b-b8fe-4cfbc12b25fe
date added to LUP
2024-02-07 15:58:25
date last changed
2024-04-23 22:48:37
@article{7ea59b9b-a101-4c2b-b8fe-4cfbc12b25fe,
  abstract     = {{<p>Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.</p>}},
  author       = {{Engström, Gunnar and Lampa, Erik and Dekkers, Koen and Lin, Yi Ting and Ahlm, Kristin and Ahlström, Håkan and Alfredsson, Joakim and Bergström, Göran and Blomberg, Anders and Brandberg, John and Caidahl, Kenneth and Cederlund, Kerstin and Duvernoy, Olov and Engvall, Jan E. and Eriksson, Maria J. and Fall, Tove and Gigante, Bruna and Gummesson, Anders and Hagström, Emil and Hamrefors, Viktor and Hedner, Jan and Janzon, Magnus and Jernberg, Tomas and Johnson, Linda and Lind, Lars and Lindberg, Eva and Mannila, Maria and Nilsson, Ulf and Persson, Anders and Persson, Hans Lennart and Persson, Margaretha and Ramnemark, Anna and Rosengren, Annika and Schmidt, Caroline and Skoglund Larsson, Linn and Sköld, C. Magnus and Swahn, Eva and Söderberg, Stefan and Torén, Kjell and Waldenström, Anders and Wollmer, Per and Zaigham, Suneela and Östgren, Carl Johan and Sundström, Johan}},
  issn         = {{0393-2990}},
  keywords     = {{Atherosclerosis; Coronary heart disease; Emphysema; Spirometry}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{35--49}},
  publisher    = {{Springer}},
  series       = {{European Journal of Epidemiology}},
  title        = {{Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications}},
  url          = {{http://dx.doi.org/10.1007/s10654-023-01088-z}},
  doi          = {{10.1007/s10654-023-01088-z}},
  volume       = {{39}},
  year         = {{2024}},
}