Solid-state and diffusion NMR spectroscopy as applied to characterization of complex formulated products and biological materials
(2016) 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference 1. p.304-307- Abstract
Solid-state and diffusion NMR spectroscopy are versatile tools that allow for studies of both structure and dynamics of complex solid and semisolid materials. We have developed a suit of pulse sequences based on polarization transfer that is readily applied to studies of formulations and their interactions with biological systems. In the present paper, we illustrate its applicability by using an incompletely hydrated surfactant system (tetradecyl-maltoside, C14G2) and skin (stratum corneum, SC) as examples. In the former case, solid-state NMR has allowed us to study the dynamics of the system at the level of individual functional groups, and also to derive the surprisingly complex... (More)
Solid-state and diffusion NMR spectroscopy are versatile tools that allow for studies of both structure and dynamics of complex solid and semisolid materials. We have developed a suit of pulse sequences based on polarization transfer that is readily applied to studies of formulations and their interactions with biological systems. In the present paper, we illustrate its applicability by using an incompletely hydrated surfactant system (tetradecyl-maltoside, C14G2) and skin (stratum corneum, SC) as examples. In the former case, solid-state NMR has allowed us to study the dynamics of the system at the level of individual functional groups, and also to derive the surprisingly complex C14G2-H2O phase diagram at water contents <5%. For SC, NMR data has allowed us to study the effect of natural moisturizing factor (NMF) on the dynamics of its lipid and protein constituents. The results challenge the conventional view that NMF protects the skin from dryness by increasing its water content.
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- author
- Ulvenlund, S. ; Topgaard, D. LU ; Sparr, E. LU and Gustavsson, S. LU
- organization
- publishing date
- 2016
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Formulated products, Glass transition, NMR, Phase diagram, Skin, Stratum corneum
- host publication
- Advanced Materials - TechConnect Briefs 2016
- volume
- 1
- pages
- 4 pages
- publisher
- TechConnect
- conference name
- 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
- conference location
- Washington, United States
- conference dates
- 2016-05-22 - 2016-05-25
- external identifiers
-
- scopus:84988847761
- ISBN
- 9780997511703
- language
- English
- LU publication?
- yes
- id
- 7f38a30f-8ea6-47ab-8280-e12bade0be59
- date added to LUP
- 2017-02-16 11:21:24
- date last changed
- 2022-01-30 17:59:15
@inproceedings{7f38a30f-8ea6-47ab-8280-e12bade0be59, abstract = {{<p>Solid-state and diffusion NMR spectroscopy are versatile tools that allow for studies of both structure and dynamics of complex solid and semisolid materials. We have developed a suit of pulse sequences based on polarization transfer that is readily applied to studies of formulations and their interactions with biological systems. In the present paper, we illustrate its applicability by using an incompletely hydrated surfactant system (tetradecyl-maltoside, C<sub>14</sub>G<sub>2</sub>) and skin (stratum corneum, SC) as examples. In the former case, solid-state NMR has allowed us to study the dynamics of the system at the level of individual functional groups, and also to derive the surprisingly complex C<sub>14</sub>G<sub>2</sub>-H<sub>2</sub>O phase diagram at water contents <5%. For SC, NMR data has allowed us to study the effect of natural moisturizing factor (NMF) on the dynamics of its lipid and protein constituents. The results challenge the conventional view that NMF protects the skin from dryness by increasing its water content.</p>}}, author = {{Ulvenlund, S. and Topgaard, D. and Sparr, E. and Gustavsson, S.}}, booktitle = {{Advanced Materials - TechConnect Briefs 2016}}, isbn = {{9780997511703}}, keywords = {{Formulated products; Glass transition; NMR; Phase diagram; Skin; Stratum corneum}}, language = {{eng}}, pages = {{304--307}}, publisher = {{TechConnect}}, title = {{Solid-state and diffusion NMR spectroscopy as applied to characterization of complex formulated products and biological materials}}, volume = {{1}}, year = {{2016}}, }