Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study
(2013) In British Journal of Cancer 108(4). p.812-819- Abstract
- Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease.... (More)
- Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (Cl) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% Cl 2.20-140). Conclusion: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3760978
- author
- Holmberg, L. ; Wong, Y. N. S. ; Tabar, L. ; Ringberg, Anita LU ; Karlsson, P. ; Arnesson, L-G ; Sandelin, K. ; Anderson, Harald LU ; Garmo, H. and Emdin, S.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DCIS, ipsilateral recurrence, mammographic calcifications, radiotherapy, breast-conserving surgery, randomised trial
- in
- British Journal of Cancer
- volume
- 108
- issue
- 4
- pages
- 812 - 819
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000316775900011
- scopus:84875225409
- pmid:23370209
- ISSN
- 1532-1827
- DOI
- 10.1038/bjc.2013.26
- language
- English
- LU publication?
- yes
- id
- 7fdd525a-f95b-4f8d-a6cc-8fc4d8e55d0e (old id 3760978)
- date added to LUP
- 2016-04-01 10:23:25
- date last changed
- 2022-02-25 01:15:00
@article{7fdd525a-f95b-4f8d-a6cc-8fc4d8e55d0e, abstract = {{Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (Cl) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% Cl 2.20-140). Conclusion: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women.}}, author = {{Holmberg, L. and Wong, Y. N. S. and Tabar, L. and Ringberg, Anita and Karlsson, P. and Arnesson, L-G and Sandelin, K. and Anderson, Harald and Garmo, H. and Emdin, S.}}, issn = {{1532-1827}}, keywords = {{DCIS; ipsilateral recurrence; mammographic calcifications; radiotherapy; breast-conserving surgery; randomised trial}}, language = {{eng}}, number = {{4}}, pages = {{812--819}}, publisher = {{Nature Publishing Group}}, series = {{British Journal of Cancer}}, title = {{Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study}}, url = {{http://dx.doi.org/10.1038/bjc.2013.26}}, doi = {{10.1038/bjc.2013.26}}, volume = {{108}}, year = {{2013}}, }