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Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study

Holmberg, L.; Wong, Y. N. S.; Tabar, L.; Ringberg, Anita LU ; Karlsson, P.; Arnesson, L-G; Sandelin, K.; Anderson, Harald LU ; Garmo, H. and Emdin, S. (2013) In British Journal of Cancer 108(4). p.812-819
Abstract
Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease.... (More)
Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (Cl) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% Cl 2.20-140). Conclusion: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DCIS, ipsilateral recurrence, mammographic calcifications, radiotherapy, breast-conserving surgery, randomised trial
in
British Journal of Cancer
volume
108
issue
4
pages
812 - 819
publisher
Nature Publishing Group
external identifiers
  • wos:000316775900011
  • scopus:84875225409
ISSN
1532-1827
DOI
10.1038/bjc.2013.26
language
English
LU publication?
yes
id
7fdd525a-f95b-4f8d-a6cc-8fc4d8e55d0e (old id 3760978)
date added to LUP
2013-06-03 08:40:01
date last changed
2019-03-19 01:14:02
@article{7fdd525a-f95b-4f8d-a6cc-8fc4d8e55d0e,
  abstract     = {Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (Cl) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% Cl 2.20-140). Conclusion: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women.},
  author       = {Holmberg, L. and Wong, Y. N. S. and Tabar, L. and Ringberg, Anita and Karlsson, P. and Arnesson, L-G and Sandelin, K. and Anderson, Harald and Garmo, H. and Emdin, S.},
  issn         = {1532-1827},
  keyword      = {DCIS,ipsilateral recurrence,mammographic calcifications,radiotherapy,breast-conserving surgery,randomised trial},
  language     = {eng},
  number       = {4},
  pages        = {812--819},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study},
  url          = {http://dx.doi.org/10.1038/bjc.2013.26},
  volume       = {108},
  year         = {2013},
}