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Serum choline in extremely preterm infants declines with increasing parenteral nutrition

Nilsson, Anders K. ; Pedersen, Anders ; Malmodin, Daniel ; Lund, Anna My LU ; Hellgren, Gunnel ; Löfqvist, Chatarina ; Pupp, Ingrid Hansen LU and Hellström, Ann LU (2020) In European Journal of Nutrition
Abstract

Purpose: Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants received during the first 28 postnatal days (PNDs). Methods: This prospective study included 87 infants born at gestational age (GA) < 28 weeks. Infant serum samples were collected PND 1, 7, 14, and 28, and at postmenstrual age (PMA) 32, 36, and 40 weeks.... (More)

Purpose: Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants received during the first 28 postnatal days (PNDs). Methods: This prospective study included 87 infants born at gestational age (GA) < 28 weeks. Infant serum samples were collected PND 1, 7, 14, and 28, and at postmenstrual age (PMA) 32, 36, and 40 weeks. The serum concentrations of free choline, betaine, and methionine were determined by 1H NMR spectroscopy. Results: The median (25th–75th percentile) serum concentrations of free choline, betaine, and methionine were 33.7 (26.2–41.2), 71.2 (53.2–100.8), and 25.6 (16.4–35.3) µM, respectively, at PND 1. The choline concentration decreased rapidly between PND one and PND seven [18.4 (14.1–26.4) µM], and then increased over the next 90 days, though never reaching PND one levels. There was a negative correlation between a high intake of parenteral fluids and serum-free choline. Conclusion: Circulating free choline in extremely preterm infants is negatively affected by the proportion of parenteral fluids administered. Trial registration: ClinicalTrials.gov Identifier NCT02760472, April 29, 2016, retrospectively registered.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Betaine, Enteral nutrition, Human milk, Methionine, Phosphatidylcholine, Proton nuclear magnetic resonance
in
European Journal of Nutrition
publisher
Springer
external identifiers
  • scopus:85087042292
  • pmid:32588218
ISSN
1436-6207
DOI
10.1007/s00394-020-02312-2
language
English
LU publication?
yes
id
7fffe6da-46f1-4659-9430-90889721332a
date added to LUP
2020-07-13 13:16:13
date last changed
2021-01-06 02:46:12
@article{7fffe6da-46f1-4659-9430-90889721332a,
  abstract     = {<p>Purpose: Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants received during the first 28 postnatal days (PNDs). Methods: This prospective study included 87 infants born at gestational age (GA) &lt; 28 weeks. Infant serum samples were collected PND 1, 7, 14, and 28, and at postmenstrual age (PMA) 32, 36, and 40 weeks. The serum concentrations of free choline, betaine, and methionine were determined by <sup>1</sup>H NMR spectroscopy. Results: The median (25th–75th percentile) serum concentrations of free choline, betaine, and methionine were 33.7 (26.2–41.2), 71.2 (53.2–100.8), and 25.6 (16.4–35.3) µM, respectively, at PND 1. The choline concentration decreased rapidly between PND one and PND seven [18.4 (14.1–26.4) µM], and then increased over the next 90 days, though never reaching PND one levels. There was a negative correlation between a high intake of parenteral fluids and serum-free choline. Conclusion: Circulating free choline in extremely preterm infants is negatively affected by the proportion of parenteral fluids administered. Trial registration: ClinicalTrials.gov Identifier NCT02760472, April 29, 2016, retrospectively registered.</p>},
  author       = {Nilsson, Anders K. and Pedersen, Anders and Malmodin, Daniel and Lund, Anna My and Hellgren, Gunnel and Löfqvist, Chatarina and Pupp, Ingrid Hansen and Hellström, Ann},
  issn         = {1436-6207},
  language     = {eng},
  month        = {06},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Serum choline in extremely preterm infants declines with increasing parenteral nutrition},
  url          = {http://dx.doi.org/10.1007/s00394-020-02312-2},
  doi          = {10.1007/s00394-020-02312-2},
  year         = {2020},
}