Hypocalcaemia after total thyroidectomy for Graves' disease and for benign atoxic multinodular goitre.
(2012) In Langenbeck's Archives of Surgery 397(7). p.1133-1137- Abstract
- PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with... (More)
- PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with Mann-Whitney, chi(2) and Fishers' exact test where appropriate and by multivariable logistic regression analysis. RESULTS: There were 128 patients with Graves' disease and 81 patients with MNG. Patients with Graves' disease were younger than patients with MNG (median age, 35 vs 51 years, p < 0.001). Symptoms of hypocalcaemia were more common in patients with Graves' disease (p < 0.001; OR, 95 % CI 3.26, 1.48-7.14), but the frequency of biochemical hypocalcaemia, postoperative levels of parathyroid hormone (PTH) and treatment with calcium and vitamin D did not differ between groups of patients. CONCLUSION: Apart from more frequent symptoms of hypocalcaemia in patients with Graves' disease, there was no difference in the overall frequency of biochemical hypocalcaemia, low levels of PTH and/or treatment with calcium and vitamin D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3123948
- author
- Hallgrimsson, Palli LU ; Nordenström, Erik LU ; Bergenfelz, Anders LU and Almquist, Martin LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langenbeck's Archives of Surgery
- volume
- 397
- issue
- 7
- pages
- 1133 - 1137
- publisher
- Springer
- external identifiers
-
- wos:000310393000014
- pmid:22976368
- scopus:84868194984
- ISSN
- 1435-2451
- DOI
- 10.1007/s00423-012-0981-1
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery (Lund) (013009000), Emergency medicine/Medicine/Surgery (013240200)
- id
- 80226cef-32a8-435b-a0ca-d7c86502fe4b (old id 3123948)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22976368?dopt=Abstract
- date added to LUP
- 2016-04-04 09:03:33
- date last changed
- 2022-03-15 17:32:29
@article{80226cef-32a8-435b-a0ca-d7c86502fe4b, abstract = {{PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with Mann-Whitney, chi(2) and Fishers' exact test where appropriate and by multivariable logistic regression analysis. RESULTS: There were 128 patients with Graves' disease and 81 patients with MNG. Patients with Graves' disease were younger than patients with MNG (median age, 35 vs 51 years, p < 0.001). Symptoms of hypocalcaemia were more common in patients with Graves' disease (p < 0.001; OR, 95 % CI 3.26, 1.48-7.14), but the frequency of biochemical hypocalcaemia, postoperative levels of parathyroid hormone (PTH) and treatment with calcium and vitamin D did not differ between groups of patients. CONCLUSION: Apart from more frequent symptoms of hypocalcaemia in patients with Graves' disease, there was no difference in the overall frequency of biochemical hypocalcaemia, low levels of PTH and/or treatment with calcium and vitamin D.}}, author = {{Hallgrimsson, Palli and Nordenström, Erik and Bergenfelz, Anders and Almquist, Martin}}, issn = {{1435-2451}}, language = {{eng}}, number = {{7}}, pages = {{1133--1137}}, publisher = {{Springer}}, series = {{Langenbeck's Archives of Surgery}}, title = {{Hypocalcaemia after total thyroidectomy for Graves' disease and for benign atoxic multinodular goitre.}}, url = {{http://dx.doi.org/10.1007/s00423-012-0981-1}}, doi = {{10.1007/s00423-012-0981-1}}, volume = {{397}}, year = {{2012}}, }