Cholesterol in women at high cardiovascular risk is less successfully treated than in corresponding men
(2008) In European Journal of Clinical Pharmacology 64(8). p.815-820- Abstract
- Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering... (More)
- Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering therapy. A higher fraction of women were treated; however only 13% of them reached target cholesterol levels compared to 37% of the men (P<0.001). Sixty-five subjects (9.0%) had diabetes and/or a previous stroke (29 men, 36 women) but no previous CHD. Patients with CHD were more likely to be treated compared to patients with diabetes and/or stroke but no CHD (85.0 vs. 28.5%, OR 6.0, 95% CI 2.2-16.9, P=0.01). In a total of 79 participants (10.9%) who were on lipid-lowering therapy, women reached a total serum cholesterol level below 5.0 mmol/L less often than men (26.3 vs. 63.4%, P<0.001). Conclusions A considerable proportion of patients in primary care were untreated despite current guidelines on lipid-lowering therapy. Treatment outcome in women was less efficient compared with men. Strategies to improve pharmacological treatment in these patients should be developed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1191081
- author
- Mehner, Anita ; Lindblad, Ulf LU ; Råstam, Lennart LU and Bengtsson Boström, Kristina LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- coronary heart disease, primary care, lipid-lowering drugs, guidelines, diabetes, cerebrovascular disease
- in
- European Journal of Clinical Pharmacology
- volume
- 64
- issue
- 8
- pages
- 815 - 820
- publisher
- Springer
- external identifiers
-
- wos:000256927900008
- scopus:45849128695
- pmid:18389228
- ISSN
- 1432-1041
- DOI
- 10.1007/s00228-008-0482-x
- language
- English
- LU publication?
- yes
- id
- 80243f9a-9432-414d-8fcc-9e3b39fee28f (old id 1191081)
- date added to LUP
- 2016-04-01 13:38:23
- date last changed
- 2024-01-09 16:22:55
@article{80243f9a-9432-414d-8fcc-9e3b39fee28f, abstract = {{Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews. Results Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering therapy. A higher fraction of women were treated; however only 13% of them reached target cholesterol levels compared to 37% of the men (P<0.001). Sixty-five subjects (9.0%) had diabetes and/or a previous stroke (29 men, 36 women) but no previous CHD. Patients with CHD were more likely to be treated compared to patients with diabetes and/or stroke but no CHD (85.0 vs. 28.5%, OR 6.0, 95% CI 2.2-16.9, P=0.01). In a total of 79 participants (10.9%) who were on lipid-lowering therapy, women reached a total serum cholesterol level below 5.0 mmol/L less often than men (26.3 vs. 63.4%, P<0.001). Conclusions A considerable proportion of patients in primary care were untreated despite current guidelines on lipid-lowering therapy. Treatment outcome in women was less efficient compared with men. Strategies to improve pharmacological treatment in these patients should be developed.}}, author = {{Mehner, Anita and Lindblad, Ulf and Råstam, Lennart and Bengtsson Boström, Kristina}}, issn = {{1432-1041}}, keywords = {{coronary heart disease; primary care; lipid-lowering drugs; guidelines; diabetes; cerebrovascular disease}}, language = {{eng}}, number = {{8}}, pages = {{815--820}}, publisher = {{Springer}}, series = {{European Journal of Clinical Pharmacology}}, title = {{Cholesterol in women at high cardiovascular risk is less successfully treated than in corresponding men}}, url = {{http://dx.doi.org/10.1007/s00228-008-0482-x}}, doi = {{10.1007/s00228-008-0482-x}}, volume = {{64}}, year = {{2008}}, }