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Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain

Blomqvist, Photjanee ; Lindvall, Olle LU and Wieloch, Tadeusz LU (1985) In Neuroscience Letters 58(3). p.353-358
Abstract

The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hippocampus, ischemia, locus coeruleus, neuronal damage, noradrenaline, rat
in
Neuroscience Letters
volume
58
issue
3
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:4047495
  • scopus:0022389997
ISSN
0304-3940
DOI
10.1016/0304-3940(85)90080-1
language
English
LU publication?
yes
id
802e8393-e6ed-4d81-8133-9fb86f7be878
date added to LUP
2019-06-13 17:52:05
date last changed
2024-01-01 10:36:16
@article{802e8393-e6ed-4d81-8133-9fb86f7be878,
  abstract     = {{<p>The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.</p>}},
  author       = {{Blomqvist, Photjanee and Lindvall, Olle and Wieloch, Tadeusz}},
  issn         = {{0304-3940}},
  keywords     = {{hippocampus; ischemia; locus coeruleus; neuronal damage; noradrenaline; rat}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{3}},
  pages        = {{353--358}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain}},
  url          = {{http://dx.doi.org/10.1016/0304-3940(85)90080-1}},
  doi          = {{10.1016/0304-3940(85)90080-1}},
  volume       = {{58}},
  year         = {{1985}},
}