Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain
(1985) In Neuroscience Letters 58(3). p.353-358- Abstract
The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/802e8393-e6ed-4d81-8133-9fb86f7be878
- author
- Blomqvist, Photjanee ; Lindvall, Olle LU and Wieloch, Tadeusz LU
- organization
- publishing date
- 1985-08-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hippocampus, ischemia, locus coeruleus, neuronal damage, noradrenaline, rat
- in
- Neuroscience Letters
- volume
- 58
- issue
- 3
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:4047495
- scopus:0022389997
- ISSN
- 0304-3940
- DOI
- 10.1016/0304-3940(85)90080-1
- language
- English
- LU publication?
- yes
- id
- 802e8393-e6ed-4d81-8133-9fb86f7be878
- date added to LUP
- 2019-06-13 17:52:05
- date last changed
- 2024-01-01 10:36:16
@article{802e8393-e6ed-4d81-8133-9fb86f7be878, abstract = {{<p>The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.</p>}}, author = {{Blomqvist, Photjanee and Lindvall, Olle and Wieloch, Tadeusz}}, issn = {{0304-3940}}, keywords = {{hippocampus; ischemia; locus coeruleus; neuronal damage; noradrenaline; rat}}, language = {{eng}}, month = {{08}}, number = {{3}}, pages = {{353--358}}, publisher = {{Elsevier}}, series = {{Neuroscience Letters}}, title = {{Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain}}, url = {{http://dx.doi.org/10.1016/0304-3940(85)90080-1}}, doi = {{10.1016/0304-3940(85)90080-1}}, volume = {{58}}, year = {{1985}}, }