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Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

Nilsson, Emma A LU ; Matte, Ashok; Perfilyev, Alexander LU ; de Mello, Vanessa D; Käkelä, Pirjo; Pihlajamäki, Jussi and Ling, Charlotte LU (2015) In Journal of Clinical Endocrinology and Metabolism 100(11). p.1491-1501
Abstract
Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
100
issue
11
pages
1491 - 1501
publisher
The Endocrine Society
external identifiers
  • pmid:26418287
  • wos:000364925700023
  • scopus:84958673442
ISSN
1945-7197
DOI
10.1210/jc.2015-3204
language
English
LU publication?
yes
id
9b192333-b505-4b12-acf4-5e88c7f6277c (old id 8034507)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26418287?dopt=Abstract
date added to LUP
2015-10-03 12:38:38
date last changed
2017-10-22 03:17:52
@article{9b192333-b505-4b12-acf4-5e88c7f6277c,
  abstract     = {Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.},
  author       = {Nilsson, Emma A and Matte, Ashok and Perfilyev, Alexander and de Mello, Vanessa D and Käkelä, Pirjo and Pihlajamäki, Jussi and Ling, Charlotte},
  issn         = {1945-7197},
  language     = {eng},
  number       = {11},
  pages        = {1491--1501},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.},
  url          = {http://dx.doi.org/10.1210/jc.2015-3204},
  volume       = {100},
  year         = {2015},
}