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Phase Segregation in Individually Dried Particles Composed of Biopolymers.

Nuzzo, Marine LU ; Sloth, Jakob; Bergenståhl, Björn LU and Millqvist-Fureby, Anna (2015) In Langmuir 31(40). p.10946-10954
Abstract
Mixing of two biopolymers can results in phase separation due to their thermodynamically incompatibility under certain conditions. This phenomenon was first reported when the solution was allowed to equilibrate, but it has later been observed also as a consequence of drying. The challenges of this study were to observe phase segregation by confocal Raman microscopy and LV-SEM on dried film, individually dried particles, and spray dried particles. The influence of the solid content and the phase ratio (composition) of a HPMC/maltodextrin mixture on the localization of the ingredients in the individually dried particles was investigated. We observed that phase segregation of HPMC and maltodextrin is induced by solvent evaporation in film... (More)
Mixing of two biopolymers can results in phase separation due to their thermodynamically incompatibility under certain conditions. This phenomenon was first reported when the solution was allowed to equilibrate, but it has later been observed also as a consequence of drying. The challenges of this study were to observe phase segregation by confocal Raman microscopy and LV-SEM on dried film, individually dried particles, and spray dried particles. The influence of the solid content and the phase ratio (composition) of a HPMC/maltodextrin mixture on the localization of the ingredients in the individually dried particles was investigated. We observed that phase segregation of HPMC and maltodextrin is induced by solvent evaporation in film drying, single particle drying, as well as spray drying. The phase ratio is an important parameter that influences the localization of the HPMC-enriched phase and maltodextrin-enriched phase, i.e., to the particle surface, to the core, or in a more or less bicontinuous pattern. The drying time, affected by the solids content, was found to control the level of advancement of the phase segregation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
31
issue
40
pages
10946 - 10954
publisher
The American Chemical Society
external identifiers
  • pmid:26397315
  • wos:000362920900003
  • scopus:84944145422
ISSN
0743-7463
DOI
10.1021/acs.langmuir.5b02023
language
English
LU publication?
yes
id
bc8641be-2a87-4078-a989-aca37e512a21 (old id 8035165)
date added to LUP
2015-10-30 13:03:42
date last changed
2017-09-24 03:17:43
@article{bc8641be-2a87-4078-a989-aca37e512a21,
  abstract     = {Mixing of two biopolymers can results in phase separation due to their thermodynamically incompatibility under certain conditions. This phenomenon was first reported when the solution was allowed to equilibrate, but it has later been observed also as a consequence of drying. The challenges of this study were to observe phase segregation by confocal Raman microscopy and LV-SEM on dried film, individually dried particles, and spray dried particles. The influence of the solid content and the phase ratio (composition) of a HPMC/maltodextrin mixture on the localization of the ingredients in the individually dried particles was investigated. We observed that phase segregation of HPMC and maltodextrin is induced by solvent evaporation in film drying, single particle drying, as well as spray drying. The phase ratio is an important parameter that influences the localization of the HPMC-enriched phase and maltodextrin-enriched phase, i.e., to the particle surface, to the core, or in a more or less bicontinuous pattern. The drying time, affected by the solids content, was found to control the level of advancement of the phase segregation.},
  author       = {Nuzzo, Marine and Sloth, Jakob and Bergenståhl, Björn and Millqvist-Fureby, Anna},
  issn         = {0743-7463},
  language     = {eng},
  number       = {40},
  pages        = {10946--10954},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Phase Segregation in Individually Dried Particles Composed of Biopolymers.},
  url          = {http://dx.doi.org/10.1021/acs.langmuir.5b02023},
  volume       = {31},
  year         = {2015},
}