Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.
(2015) In Biomaterials research 19(19). p.1-10- Abstract
- The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed... (More)
- The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8035179
- author
- Ejserholm, Fredrik LU ; Stegmayr, John LU ; Bauer, Patrik ; Johansson, Fredrik LU ; Wallman, Lars LU ; Bengtsson, Martin LU and Oredsson, Stina
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomaterials research
- volume
- 19
- issue
- 19
- pages
- 1 - 10
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26396744
- pmid:26396744
- scopus:85020427489
- ISSN
- 2055-7124
- DOI
- 10.1186/s40824-015-0041-3
- language
- English
- LU publication?
- yes
- id
- 3a604b93-ac68-4dbe-999f-22fa6f75093d (old id 8035179)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26396744?dopt=Abstract
- date added to LUP
- 2016-04-01 13:52:14
- date last changed
- 2022-04-06 07:33:49
@article{3a604b93-ac68-4dbe-999f-22fa6f75093d, abstract = {{The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals.}}, author = {{Ejserholm, Fredrik and Stegmayr, John and Bauer, Patrik and Johansson, Fredrik and Wallman, Lars and Bengtsson, Martin and Oredsson, Stina}}, issn = {{2055-7124}}, language = {{eng}}, number = {{19}}, pages = {{1--10}}, publisher = {{BioMed Central (BMC)}}, series = {{Biomaterials research}}, title = {{Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.}}, url = {{https://lup.lub.lu.se/search/files/3637318/8852380.pdf}}, doi = {{10.1186/s40824-015-0041-3}}, volume = {{19}}, year = {{2015}}, }