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Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.

Ejserholm, Fredrik LU ; Stegmayr, John LU ; Bauer, Patrik; Johansson, Fredrik LU ; Wallman, Lars LU ; Bengtsson, Martin LU and Oredsson, Stina (2015) In Biomaterials research 19(19). p.1-10
Abstract
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed... (More)
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomaterials research
volume
19
issue
19
pages
1 - 10
publisher
BioMed Central
external identifiers
  • pmid:26396744
ISSN
2055-7124
DOI
10.1186/s40824-015-0041-3
language
English
LU publication?
yes
id
3a604b93-ac68-4dbe-999f-22fa6f75093d (old id 8035179)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26396744?dopt=Abstract
date added to LUP
2015-10-03 16:24:59
date last changed
2016-09-20 04:23:31
@article{3a604b93-ac68-4dbe-999f-22fa6f75093d,
  abstract     = {The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals.},
  author       = {Ejserholm, Fredrik and Stegmayr, John and Bauer, Patrik and Johansson, Fredrik and Wallman, Lars and Bengtsson, Martin and Oredsson, Stina},
  issn         = {2055-7124},
  language     = {eng},
  number       = {19},
  pages        = {1--10},
  publisher    = {BioMed Central},
  series       = {Biomaterials research},
  title        = {Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.},
  url          = {http://dx.doi.org/10.1186/s40824-015-0041-3},
  volume       = {19},
  year         = {2015},
}