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Noninvasive characterization of atrioventricular conduction in patients with atrial fibrillation.

Corino, Valentina D A; Sandberg, Frida LU ; Mainardi, Luca T; Platonov, Pyotr LU and Sörnmo, Leif LU (2015) In Journal of Electrocardiology 48(6). p.938-942
Abstract
The atrioventricular (AV) node plays a fundamental role in patients with atrial fibrillation (AF), acting as a filter to the numerous irregular atrial impulses which bombard the node. A phenomenological approach to better understand AV nodal electrophysiology is to analyze the ventricular response with respect to irregularity. In different cohorts of AF patients, such analysis has been performed with the aim to evaluate the association between ventricular response characteristics and long-term clinical outcome and to determine whether irregularity is affected by rate-control drugs. Another approach to studying AV nodal characteristics is to employ a mathematical model which accounts for the refractory periods of the two AV nodal pathways.... (More)
The atrioventricular (AV) node plays a fundamental role in patients with atrial fibrillation (AF), acting as a filter to the numerous irregular atrial impulses which bombard the node. A phenomenological approach to better understand AV nodal electrophysiology is to analyze the ventricular response with respect to irregularity. In different cohorts of AF patients, such analysis has been performed with the aim to evaluate the association between ventricular response characteristics and long-term clinical outcome and to determine whether irregularity is affected by rate-control drugs. Another approach to studying AV nodal characteristics is to employ a mathematical model which accounts for the refractory periods of the two AV nodal pathways. With atrial fibrillatory rate and RR intervals as input, the model has been considered for analyzing data during (i) rest and head-up tilt test, (ii) tecadenoson and esmolol, and (iii) rate-control drugs. The present paper provides an overview of our recent work on the characterization and assessment of AV nodal conduction using these two approaches. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Electrocardiology
volume
48
issue
6
pages
938 - 942
publisher
Elsevier
external identifiers
  • pmid:26324177
  • wos:000364896800004
  • scopus:84952864656
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2015.08.010
language
English
LU publication?
yes
id
5568080a-1cbb-44db-9f99-5adc0a1e004e (old id 8043602)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26324177?dopt=Abstract
date added to LUP
2015-10-07 22:40:54
date last changed
2017-08-09 14:39:54
@article{5568080a-1cbb-44db-9f99-5adc0a1e004e,
  abstract     = {The atrioventricular (AV) node plays a fundamental role in patients with atrial fibrillation (AF), acting as a filter to the numerous irregular atrial impulses which bombard the node. A phenomenological approach to better understand AV nodal electrophysiology is to analyze the ventricular response with respect to irregularity. In different cohorts of AF patients, such analysis has been performed with the aim to evaluate the association between ventricular response characteristics and long-term clinical outcome and to determine whether irregularity is affected by rate-control drugs. Another approach to studying AV nodal characteristics is to employ a mathematical model which accounts for the refractory periods of the two AV nodal pathways. With atrial fibrillatory rate and RR intervals as input, the model has been considered for analyzing data during (i) rest and head-up tilt test, (ii) tecadenoson and esmolol, and (iii) rate-control drugs. The present paper provides an overview of our recent work on the characterization and assessment of AV nodal conduction using these two approaches.},
  author       = {Corino, Valentina D A and Sandberg, Frida and Mainardi, Luca T and Platonov, Pyotr and Sörnmo, Leif},
  issn         = {1532-8430},
  language     = {eng},
  number       = {6},
  pages        = {938--942},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {Noninvasive characterization of atrioventricular conduction in patients with atrial fibrillation.},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2015.08.010},
  volume       = {48},
  year         = {2015},
}