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Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Bakalkin, Georgy ; Nosova, Olga ; Sarkisyan, Daniil ; Hallberg, Mathias ; Zhang, Mengliang LU ; Schouenborg, Jens LU orcid ; Marklund, Niklas LU orcid and Watanabe, Hiroyuki LU (2021) In Experimental Brain Research 239(7). p.2221-2232
Abstract

Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb postural asymmetry (HL-PA) with contralesional or ipsilesional limb flexion. The contralesional hindlimb was flexed after left or right side ablation injury. In contrast, both the left and right CCI unexpectedly produced HL-PA with flexion on left side. The flexion persisted after complete spinal cord transection suggesting that CCI triggered... (More)

Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb postural asymmetry (HL-PA) with contralesional or ipsilesional limb flexion. The contralesional hindlimb was flexed after left or right side ablation injury. In contrast, both the left and right CCI unexpectedly produced HL-PA with flexion on left side. The flexion persisted after complete spinal cord transection suggesting that CCI triggered neuroplastic processes in lumbar neural circuits enabling asymmetric muscle contraction. Left limb flexion was exhibited under pentobarbital anesthesia. However, under ketamine anesthesia, the body of the left and right CCI rats bent laterally in the coronal plane to the ipsilesional side suggesting that the left and right injury engaged mirror-symmetrical motor pathways. Thus, the effects of the left and right CCI on HL-PA were not mirror-symmetrical in contrast to those of the ablation brain injury, and to the left and right CCI produced body bending. Ipsilateral effects of the left CCI on HL-PA may be mediated by a lateralized motor pathway that is not affected by the left ablation injury. Alternatively, the left-side-specific neurohormonal mechanism that signals from injured brain to spinal cord may be activated by both the left and right CCI but not by ablation injury.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Contralateral response, Ipsilateral response, Postural asymmetry, Stroke, Traumatic brain injury
in
Experimental Brain Research
volume
239
issue
7
pages
2221 - 2232
publisher
Springer
external identifiers
  • scopus:85106450522
  • pmid:34021800
ISSN
0014-4819
DOI
10.1007/s00221-021-06118-4
language
English
LU publication?
yes
id
80585f05-faa1-4cba-9957-cf6a786c87c3
date added to LUP
2021-06-18 12:49:23
date last changed
2024-06-15 12:43:02
@article{80585f05-faa1-4cba-9957-cf6a786c87c3,
  abstract     = {{<p>Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb postural asymmetry (HL-PA) with contralesional or ipsilesional limb flexion. The contralesional hindlimb was flexed after left or right side ablation injury. In contrast, both the left and right CCI unexpectedly produced HL-PA with flexion on left side. The flexion persisted after complete spinal cord transection suggesting that CCI triggered neuroplastic processes in lumbar neural circuits enabling asymmetric muscle contraction. Left limb flexion was exhibited under pentobarbital anesthesia. However, under ketamine anesthesia, the body of the left and right CCI rats bent laterally in the coronal plane to the ipsilesional side suggesting that the left and right injury engaged mirror-symmetrical motor pathways. Thus, the effects of the left and right CCI on HL-PA were not mirror-symmetrical in contrast to those of the ablation brain injury, and to the left and right CCI produced body bending. Ipsilateral effects of the left CCI on HL-PA may be mediated by a lateralized motor pathway that is not affected by the left ablation injury. Alternatively, the left-side-specific neurohormonal mechanism that signals from injured brain to spinal cord may be activated by both the left and right CCI but not by ablation injury.</p>}},
  author       = {{Bakalkin, Georgy and Nosova, Olga and Sarkisyan, Daniil and Hallberg, Mathias and Zhang, Mengliang and Schouenborg, Jens and Marklund, Niklas and Watanabe, Hiroyuki}},
  issn         = {{0014-4819}},
  keywords     = {{Contralateral response; Ipsilateral response; Postural asymmetry; Stroke; Traumatic brain injury}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2221--2232}},
  publisher    = {{Springer}},
  series       = {{Experimental Brain Research}},
  title        = {{Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats}},
  url          = {{http://dx.doi.org/10.1007/s00221-021-06118-4}},
  doi          = {{10.1007/s00221-021-06118-4}},
  volume       = {{239}},
  year         = {{2021}},
}