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Deterministic Lateral Displacement : Challenges and Perspectives

Hochstetter, Axel ; Vernekar, Rohan ; Austin, Robert H. ; Becker, Holger ; Beech, Jason P. LU ; Fedosov, Dmitry A. ; Gompper, Gerhard ; Kim, Sung Cheol ; Smith, Joshua T. and Stolovitzky, Gustavo , et al. (2020) In ACS Nano 14(9). p.10784-10795
Abstract

The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date... (More)

The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ACS Nano
volume
14
issue
9
pages
12 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85091043486
  • pmid:32844655
ISSN
1936-0851
DOI
10.1021/acsnano.0c05186
language
English
LU publication?
yes
id
80651db7-a0b4-4cf3-ba66-c48440bc4789
date added to LUP
2020-10-20 14:00:13
date last changed
2024-06-26 23:14:49
@article{80651db7-a0b4-4cf3-ba66-c48440bc4789,
  abstract     = {{<p>The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.</p>}},
  author       = {{Hochstetter, Axel and Vernekar, Rohan and Austin, Robert H. and Becker, Holger and Beech, Jason P. and Fedosov, Dmitry A. and Gompper, Gerhard and Kim, Sung Cheol and Smith, Joshua T. and Stolovitzky, Gustavo and Tegenfeldt, Jonas O. and Wunsch, Benjamin H. and Zeming, Kerwin K. and Krüger, Timm and Inglis, David W.}},
  issn         = {{1936-0851}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{10784--10795}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Nano}},
  title        = {{Deterministic Lateral Displacement : Challenges and Perspectives}},
  url          = {{http://dx.doi.org/10.1021/acsnano.0c05186}},
  doi          = {{10.1021/acsnano.0c05186}},
  volume       = {{14}},
  year         = {{2020}},
}