Automated evaluation of normal uptake in different skeletal parts in 18F-sodium fluoride (NaF) PET/CT using a new convolutional neural network method
Lindgren Belal, Sarah LU
; Sadik, May
; Kaboteh, Reza
; Enqvist, Olof
; Ulén, Johannes
; Kjölhede, Henrik
LU
; Bratt, Ola
LU
; Edenbrandt, Lars
and Trägårdh, Elin
LU
(2017)
Annual Congress of the European Association of Nuclear Medicine (EANM)
p.479-479
- Abstract
- Introduction: Understanding normal skeletal uptake of 18F-sodium fluoride (18F-NaF) in positron emission tomography/computed tomography (PET/CT) is important for clinical interpretation. Quantification of tracer uptake in PET/CT is often performed by placing a volume of interest (VOI) to measure standard uptake values (SUVs). Manual placement of this VOI requires a subjective decision and can only measure uptake in a specific part of the bone. The aim of this study was to investigate normal 18F-NaF skeletal activity in patients with prostate cancer at a stage of the disease prior to development of bone metastases, by using a new method that quantifies uptake in entire skeletal... (More)
- Introduction: Understanding normal skeletal uptake of 18F-sodium fluoride (18F-NaF) in positron emission tomography/computed tomography (PET/CT) is important for clinical interpretation. Quantification of tracer uptake in PET/CT is often performed by placing a volume of interest (VOI) to measure standard uptake values (SUVs). Manual placement of this VOI requires a subjective decision and can only measure uptake in a specific part of the bone. The aim of this study was to investigate normal 18F-NaF skeletal activity in patients with prostate cancer at a stage of the disease prior to development of bone metastases, by using a new method that quantifies uptake in entire skeletal parts.
Material and Methods: Patients with biopsy-verified high-risk prostate cancer and a negative or inconclusive bone scintigraphy and no metastatic lesions on 18F-NaF PET/CT (performed March 2008 - June 2010) were retrospectively included (n=48). Whole-body PET scans were acquired 1-1.5 h after i.v. injection of 4 MBq/kg 18F-NaF (max 400 MBq). CT scans were obtained immediately after the PET scan. Thoracic and lumbar vertebrae, sacrum, pelvis, ribs, scapulae, clavicles and sternum were automatically segmented in the CT images, using a method based on a convolutional neural network, to obtain the volume ofeach skeletal region. The network was trained using a separate group of CT scans with manual segmentations. Mean and maximum SUV (SUVmean and SUVmax) were subsequently measured for each skeletal part in the PET scans.
Results: Average (SD) SUVmean for the skeletal regions were: Thoracic vertebrae 0.98 (0.20), lumbar vertebrae 0.96 (0.19), sacrum 0.75 (0.15), pelvis 0.73 (0.16), ribs 0.41 (0.11), scapulae 0.46 (0.11), clavicles 0.50 (0.16) and sternum 0.61 (0.13). Average (SD) SUVmax for the skeletal regions were: Thoracic vertebrae 1.95 (0.66), lumbar vertebrae 2.10 (0.78), sacrum 2.22 (0.77), pelvis 1.99 (0.82), ribs 1.19 (0.35), scapulae 1.94 (0.98), clavicles 2.00 (1.03) and sternum 1.68 (0.44).
Conclusion: We present a new method to segment and quantify uptake in skeletal regions in 18F-NaF PET/CT. Various parts of the bone have different SUVs in patients with regional prostate cancer. Vertebrae and pelvis have higher SUVs than ribs. The highest SUVmax were found in the thoracic and lumbar vertebrae. The findings are of importance for interpretation of 18F-NaF PET/CT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8069eb9e-c791-43b3-96d0-c3c07458bba7
- author
- Lindgren Belal, Sarah
LU
; Sadik, May
; Kaboteh, Reza
; Enqvist, Olof
; Ulén, Johannes
; Kjölhede, Henrik
LU
; Bratt, Ola
LU
; Edenbrandt, Lars
and Trägårdh, Elin
LU
- organization
- publishing date
- 2017-09-11
- type
- Contribution to conference
- publication status
- published
- subject
- pages
- 1 pages
- conference name
- Annual Congress of the European Association of Nuclear Medicine (EANM)
- conference location
- Vienna, Austria
- conference dates
- 2017-10-21 - 2017-10-25
- external identifiers
-
- scopus:85057137539
- DOI
- 10.1007/s00259-017-3822-1
- language
- English
- LU publication?
- yes
- id
- 8069eb9e-c791-43b3-96d0-c3c07458bba7
- date added to LUP
- 2022-12-14 14:05:08
- date last changed
- 2023-05-15 08:37:52
@misc{8069eb9e-c791-43b3-96d0-c3c07458bba7,
abstract = {{<b>Introduction: </b>Understanding normal skeletal uptake of <sup>18</sup>F-sodium fluoride (<sup>18</sup>F-NaF) in positron emission tomography/computed tomography (PET/CT) is important for clinical interpretation. Quantification of tracer uptake in PET/CT is often performed by placing a volume of interest (VOI) to measure standard uptake values (SUVs). Manual placement of this VOI requires a subjective decision and can only measure uptake in a specific part of the bone. The aim of this study was to investigate normal <sup>18</sup>F-NaF skeletal activity in patients with prostate cancer at a stage of the disease prior to development of bone metastases, by using a new method that quantifies uptake in entire skeletal parts.<br/><b><br/>Material and Methods:</b> Patients with biopsy-verified high-risk prostate cancer and a negative or inconclusive bone scintigraphy and no metastatic lesions on <sup>18</sup>F-NaF PET/CT (performed March 2008 - June 2010) were retrospectively included (n=48). Whole-body PET scans were acquired 1-1.5 h after i.v. injection of 4 MBq/kg <sup>18</sup>F-NaF (max 400 MBq). CT scans were obtained immediately after the PET scan. Thoracic and lumbar vertebrae, sacrum, pelvis, ribs, scapulae, clavicles and sternum were automatically segmented in the CT images, using a method based on a convolutional neural network, to obtain the volume ofeach skeletal region. The network was trained using a separate group of CT scans with manual segmentations. Mean and maximum SUV (SUV<sub>mean</sub> and SUV<sub>max</sub>) were subsequently measured for each skeletal part in the PET scans.<br/><br/><b>Results:</b> Average (SD) SUVmean for the skeletal regions were: Thoracic vertebrae 0.98 (0.20), lumbar vertebrae 0.96 (0.19), sacrum 0.75 (0.15), pelvis 0.73 (0.16), ribs 0.41 (0.11), scapulae 0.46 (0.11), clavicles 0.50 (0.16) and sternum 0.61 (0.13). Average (SD) SUV<sub>max</sub> for the skeletal regions were: Thoracic vertebrae 1.95 (0.66), lumbar vertebrae 2.10 (0.78), sacrum 2.22 (0.77), pelvis 1.99 (0.82), ribs 1.19 (0.35), scapulae 1.94 (0.98), clavicles 2.00 (1.03) and sternum 1.68 (0.44).<br/><br/><b>Conclusion:</b> We present a new method to segment and quantify uptake in skeletal regions in <sup>18</sup>F-NaF PET/CT. Various parts of the bone have different SUVs in patients with regional prostate cancer. Vertebrae and pelvis have higher SUVs than ribs. The highest SUV<sub>max</sub> were found in the thoracic and lumbar vertebrae. The findings are of importance for interpretation of <sup>18</sup>F-NaF PET/CT.}},
author = {{Lindgren Belal, Sarah and Sadik, May and Kaboteh, Reza and Enqvist, Olof and Ulén, Johannes and Kjölhede, Henrik and Bratt, Ola and Edenbrandt, Lars and Trägårdh, Elin}},
language = {{eng}},
month = {{09}},
pages = {{479--479}},
title = {{Automated evaluation of normal uptake in different skeletal parts in <sup>18</sup>F-sodium fluoride (NaF) PET/CT using a new convolutional neural network method}},
url = {{http://dx.doi.org/10.1007/s00259-017-3822-1}},
doi = {{10.1007/s00259-017-3822-1}},
year = {{2017}},
}