Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C
(2015) In Infectious Diseases 47(12). p.915-918- Abstract
- Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p < 0.001) and liver biopsy (r(s) = 0.65, p < 0.001). After successful treatment of CHC,... (More)
- Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p < 0.001) and liver biopsy (r(s) = 0.65, p < 0.001). After successful treatment of CHC, COMP decreased from 18 to 13 U/l (p = 0.011). We suggest that COMP is associated with the stage of liver fibrosis in CHC. The biomarker potential of COMP in CHC warrants further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8074237
- author
- Andréasson, Kristofer LU ; Hesselstrand, Roger LU ; Saxne, Tore LU ; Holmberg, Anna LU ; Norrgren, Hans LU and Jönsson, Göran LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- COMP, chronic hepatitis C, biomarker, transient elastography, liver, fibrosis
- in
- Infectious Diseases
- volume
- 47
- issue
- 12
- pages
- 915 - 918
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000361337300012
- scopus:84962545777
- ISSN
- 2374-4243
- DOI
- 10.3109/23744235.2015.1075659
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Microbiology, Immunology and Glycobiology - MIG (013025200), Department of Rheumatology (013036000), Division of Infection Medicine (SUS) (013008000)
- id
- 251e6f27-c6ed-45b0-8c50-86c0706057ca (old id 8074237)
- date added to LUP
- 2016-04-01 15:05:06
- date last changed
- 2022-04-14 21:19:07
@article{251e6f27-c6ed-45b0-8c50-86c0706057ca, abstract = {{Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p < 0.001) and liver biopsy (r(s) = 0.65, p < 0.001). After successful treatment of CHC, COMP decreased from 18 to 13 U/l (p = 0.011). We suggest that COMP is associated with the stage of liver fibrosis in CHC. The biomarker potential of COMP in CHC warrants further investigation.}}, author = {{Andréasson, Kristofer and Hesselstrand, Roger and Saxne, Tore and Holmberg, Anna and Norrgren, Hans and Jönsson, Göran}}, issn = {{2374-4243}}, keywords = {{COMP; chronic hepatitis C; biomarker; transient elastography; liver; fibrosis}}, language = {{eng}}, number = {{12}}, pages = {{915--918}}, publisher = {{Informa Healthcare}}, series = {{Infectious Diseases}}, title = {{Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C}}, url = {{http://dx.doi.org/10.3109/23744235.2015.1075659}}, doi = {{10.3109/23744235.2015.1075659}}, volume = {{47}}, year = {{2015}}, }