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Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C

Andréasson, Kristofer LU ; Hesselstrand, Roger LU ; Saxne, Tore LU ; Holmberg, Anna LU ; Norrgren, Hans LU and Jönsson, Göran LU (2015) In Infectious Diseases 47(12). p.915-918
Abstract
Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p < 0.001) and liver biopsy (r(s) = 0.65, p < 0.001). After successful treatment of CHC,... (More)
Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p < 0.001) and liver biopsy (r(s) = 0.65, p < 0.001). After successful treatment of CHC, COMP decreased from 18 to 13 U/l (p = 0.011). We suggest that COMP is associated with the stage of liver fibrosis in CHC. The biomarker potential of COMP in CHC warrants further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COMP, chronic hepatitis C, biomarker, transient elastography, liver, fibrosis
in
Infectious Diseases
volume
47
issue
12
pages
915 - 918
publisher
Taylor & Francis
external identifiers
  • wos:000361337300012
  • scopus:84962545777
ISSN
2374-4243
DOI
10.3109/23744235.2015.1075659
language
English
LU publication?
yes
id
251e6f27-c6ed-45b0-8c50-86c0706057ca (old id 8074237)
date added to LUP
2015-11-19 10:41:03
date last changed
2017-10-22 04:28:29
@article{251e6f27-c6ed-45b0-8c50-86c0706057ca,
  abstract     = {Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis, determined by transient elastography (TE) (n = 47) and liver biopsy (n = 28) were assessed. We also studied COMP prospectively in relation to antiviral treatment (n = 10). COMP correlated with the degree of liver fibrosis as assessed by TE (r = 0.71, p &lt; 0.001) and liver biopsy (r(s) = 0.65, p &lt; 0.001). After successful treatment of CHC, COMP decreased from 18 to 13 U/l (p = 0.011). We suggest that COMP is associated with the stage of liver fibrosis in CHC. The biomarker potential of COMP in CHC warrants further investigation.},
  author       = {Andréasson, Kristofer and Hesselstrand, Roger and Saxne, Tore and Holmberg, Anna and Norrgren, Hans and Jönsson, Göran},
  issn         = {2374-4243},
  keyword      = {COMP,chronic hepatitis C,biomarker,transient elastography,liver,fibrosis},
  language     = {eng},
  number       = {12},
  pages        = {915--918},
  publisher    = {Taylor & Francis},
  series       = {Infectious Diseases},
  title        = {Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C},
  url          = {http://dx.doi.org/10.3109/23744235.2015.1075659},
  volume       = {47},
  year         = {2015},
}