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Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Sen, Abhijit; Tsilidis, Konstantinos K.; Allen, Naomi E.; Rinaldi, Sabina; Appleby, Paul N.; Almquist, Martin LU ; Schmidt, Julie A.; Dahm, Christina C.; Overvad, Kim and Tjonneland, Anne, et al. (2015) In British Journal of Cancer 113(5). p.840-847
Abstract
Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards... (More)
Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR = 0.77; 95% CI = 0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas. (Less)
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publication status
published
subject
keywords
alcohol consumption, thyroid carcinoma, prospective study, lifetime, exposure
in
British Journal of Cancer
volume
113
issue
5
pages
840 - 847
publisher
Nature Publishing Group
external identifiers
  • pmid:26313664
  • wos:000360727200019
  • scopus:84940788094
ISSN
1532-1827
DOI
10.1038/bjc.2015.280
language
English
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yes
id
51a0689b-5fa5-4133-999c-06ba2e5fb52d (old id 8077210)
date added to LUP
2015-11-19 10:39:49
date last changed
2017-07-23 03:19:50
@article{51a0689b-5fa5-4133-999c-06ba2e5fb52d,
  abstract     = {Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR = 0.77; 95% CI = 0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.},
  author       = {Sen, Abhijit and Tsilidis, Konstantinos K. and Allen, Naomi E. and Rinaldi, Sabina and Appleby, Paul N. and Almquist, Martin and Schmidt, Julie A. and Dahm, Christina C. and Overvad, Kim and Tjonneland, Anne and Rostgaard-Hansen, Agnetha L. and Clavel-Chapelon, Francoise and Baglietto, Laura and Boutron-Ruault, Marie-Christine and Kuehn, Tilman and Katze, Verena A. and Boeing, Heiner and Trichopoulou, Antonia and Tsironis, Christos and Lagiou, Pagona and Palli, Domenico and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Bueno-de-Mesquita, H. B. (as) and Peeters, Petra H. and Hjartaker, Anette and Lund, Eiliv and Weiderpass, Elisabete and Ramon Quiros, J. and Agudo, Antonio and Sanchez, Maria-Jose and Arriola, Larraitz and Gavrila, Diana and Barricarte Gurrea, Aurelio and Tosovic, Ada and Hennings, Joakim and Sandstrom, Maria and Romieu, Isabelle and Ferrari, Pietro and Zamora-Ros, Raul and Khaw, Kay-Tee and Wareham, Nicholas J. and Riboli, Elio and Gunter, Marc and Franceschi, Silvia},
  issn         = {1532-1827},
  keyword      = {alcohol consumption,thyroid carcinoma,prospective study,lifetime,exposure},
  language     = {eng},
  number       = {5},
  pages        = {840--847},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study},
  url          = {http://dx.doi.org/10.1038/bjc.2015.280},
  volume       = {113},
  year         = {2015},
}