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Experimental and Analytical Comparisons of Tissue Dielectric Constant (TDC) and Bioimpedance Spectroscopy (BIS) in Assessment of Early Arm Lymphedema in Breast Cancer Patients after Axillary Surgery and Radiotherapy

Lahtinen, Tapani; Seppala, Jan; Viren, Tuomas and Johansson, Karin LU (2015) In Lymphatic Research and Biology 13(3). p.176-185
Abstract
Background: Early diagnosis of breast cancer treatment-related lymphedema (BCRL) is of great importance for longstanding treatment results. Tissue dielectric constant (TDC) and bioimpedance spectroscopy (BIS) both have a potential for early diagnosis, but have not been compared. Methods and Results: One hundred women, treated for breast cancer with breast surgery, axillary dissection, and radiotherapy, were examined within one year after breast cancer treatment, as part of the follow-up procedure. Affected/at-risk and contralateral arms were measured with the TDC technique specific to localized skin water content and the BIS technique assessing arm extracellular fluid (ECF). Thirty-eight patients were clinically diagnosed for lymphedema... (More)
Background: Early diagnosis of breast cancer treatment-related lymphedema (BCRL) is of great importance for longstanding treatment results. Tissue dielectric constant (TDC) and bioimpedance spectroscopy (BIS) both have a potential for early diagnosis, but have not been compared. Methods and Results: One hundred women, treated for breast cancer with breast surgery, axillary dissection, and radiotherapy, were examined within one year after breast cancer treatment, as part of the follow-up procedure. Affected/at-risk and contralateral arms were measured with the TDC technique specific to localized skin water content and the BIS technique assessing arm extracellular fluid (ECF). Thirty-eight patients were clinically diagnosed for lymphedema (38.0%). The sensitivity and specificity for the TDC method were 65.8% and 83.9%, and for BIS method 42.1% and 93.5%, (p<0.001 and NS), respectively. Of all lymphedema, 18.4% were detected only by TDC and 2.6% by BIS. Affected arm to contralateral arm TDC ratios for upper arm and forearm, 1.560.49 and 1.28 +/- 0.33, demonstrating the localized feature of the TDC measurements were significantly greater than the BIS arm ratio 1.12 +/- 0.12 (both p<0.001). Conclusions: Discrepancies between TDC and BIS techniques in assessing lymphedema are related to different measurement techniques and assessed tissue water components. Independently of selected technique-specific threshold limit, the TDC technique was more sensitive than the BIS technique in the early assessment of BCRL and demonstrated that nearly 20% of early lymphedema are only superficially localized. The results further supported the complementary role of TDC and arm volume measurements as a highly diagnostic method for early lymphedema. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lymphatic Research and Biology
volume
13
issue
3
pages
176 - 185
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:26305554
  • wos:000361109400003
  • scopus:84941355030
ISSN
1539-6851
DOI
10.1089/lrb.2015.0019
language
English
LU publication?
yes
id
8a22c145-b8a7-4b7f-95c0-852dbcfc5f5c (old id 8077280)
date added to LUP
2015-11-19 10:38:24
date last changed
2017-10-22 03:17:10
@article{8a22c145-b8a7-4b7f-95c0-852dbcfc5f5c,
  abstract     = {Background: Early diagnosis of breast cancer treatment-related lymphedema (BCRL) is of great importance for longstanding treatment results. Tissue dielectric constant (TDC) and bioimpedance spectroscopy (BIS) both have a potential for early diagnosis, but have not been compared. Methods and Results: One hundred women, treated for breast cancer with breast surgery, axillary dissection, and radiotherapy, were examined within one year after breast cancer treatment, as part of the follow-up procedure. Affected/at-risk and contralateral arms were measured with the TDC technique specific to localized skin water content and the BIS technique assessing arm extracellular fluid (ECF). Thirty-eight patients were clinically diagnosed for lymphedema (38.0%). The sensitivity and specificity for the TDC method were 65.8% and 83.9%, and for BIS method 42.1% and 93.5%, (p&lt;0.001 and NS), respectively. Of all lymphedema, 18.4% were detected only by TDC and 2.6% by BIS. Affected arm to contralateral arm TDC ratios for upper arm and forearm, 1.560.49 and 1.28 +/- 0.33, demonstrating the localized feature of the TDC measurements were significantly greater than the BIS arm ratio 1.12 +/- 0.12 (both p&lt;0.001). Conclusions: Discrepancies between TDC and BIS techniques in assessing lymphedema are related to different measurement techniques and assessed tissue water components. Independently of selected technique-specific threshold limit, the TDC technique was more sensitive than the BIS technique in the early assessment of BCRL and demonstrated that nearly 20% of early lymphedema are only superficially localized. The results further supported the complementary role of TDC and arm volume measurements as a highly diagnostic method for early lymphedema.},
  author       = {Lahtinen, Tapani and Seppala, Jan and Viren, Tuomas and Johansson, Karin},
  issn         = {1539-6851},
  language     = {eng},
  number       = {3},
  pages        = {176--185},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Lymphatic Research and Biology},
  title        = {Experimental and Analytical Comparisons of Tissue Dielectric Constant (TDC) and Bioimpedance Spectroscopy (BIS) in Assessment of Early Arm Lymphedema in Breast Cancer Patients after Axillary Surgery and Radiotherapy},
  url          = {http://dx.doi.org/10.1089/lrb.2015.0019},
  volume       = {13},
  year         = {2015},
}