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Subspace-based linear multi-step predictors in type 1 diabetes mellitus

Cescon, Marzia LU ; Johansson, Rolf LU and Renard, Eric (2015) In Biomedical Signal Processing and Control 22. p.99-110
Abstract
A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The early knowledge about the effects of inputs on glycemia would provide the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this background, in this paper we propose multi-step data-driven predictors to the purpose of predicting blood glucose multiple steps ahead in the future, supporting therefore the patients when deciding upon treatments. We formulate the predictors based on the state-space construction step in subspace identification methods for linear systems. Physiological models... (More)
A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The early knowledge about the effects of inputs on glycemia would provide the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this background, in this paper we propose multi-step data-driven predictors to the purpose of predicting blood glucose multiple steps ahead in the future, supporting therefore the patients when deciding upon treatments. We formulate the predictors based on the state-space construction step in subspace identification methods for linear systems. Physiological models from the literature were used to filter the raw information on carbohydrate and insulin intakes in order to retrieve the input signals to the predictors. The clinical data of 14 type 1 diabetic patients collected in hospital during a 3-days long visit were used. Half of the data were employed for predictor development and the remaining half for validation. Mean population prediction error standard deviation on 30 min, 60 min, 90 min, 120 min ahead prediction on validation data resulted in, respectively, 19.17 mg/dL, 37.99 mg/dL, 50.62 mg/dL and 58.06 mg/dL. (C) 2014 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Subspace-based methods, Prediction theory, Diabetes
in
Biomedical Signal Processing and Control
volume
22
pages
99 - 110
publisher
Elsevier
external identifiers
  • wos:000360865100010
  • scopus:84937700747
ISSN
1746-8094
DOI
10.1016/j.bspc.2014.09.012
language
English
LU publication?
yes
id
f566eadc-1989-4448-be67-c574c871d0d1 (old id 8077545)
date added to LUP
2015-10-26 14:09:19
date last changed
2017-11-19 03:53:05
@article{f566eadc-1989-4448-be67-c574c871d0d1,
  abstract     = {A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The early knowledge about the effects of inputs on glycemia would provide the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this background, in this paper we propose multi-step data-driven predictors to the purpose of predicting blood glucose multiple steps ahead in the future, supporting therefore the patients when deciding upon treatments. We formulate the predictors based on the state-space construction step in subspace identification methods for linear systems. Physiological models from the literature were used to filter the raw information on carbohydrate and insulin intakes in order to retrieve the input signals to the predictors. The clinical data of 14 type 1 diabetic patients collected in hospital during a 3-days long visit were used. Half of the data were employed for predictor development and the remaining half for validation. Mean population prediction error standard deviation on 30 min, 60 min, 90 min, 120 min ahead prediction on validation data resulted in, respectively, 19.17 mg/dL, 37.99 mg/dL, 50.62 mg/dL and 58.06 mg/dL. (C) 2014 Elsevier Ltd. All rights reserved.},
  author       = {Cescon, Marzia and Johansson, Rolf and Renard, Eric},
  issn         = {1746-8094},
  keyword      = {Subspace-based methods,Prediction theory,Diabetes},
  language     = {eng},
  pages        = {99--110},
  publisher    = {Elsevier},
  series       = {Biomedical Signal Processing and Control},
  title        = {Subspace-based linear multi-step predictors in type 1 diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/j.bspc.2014.09.012},
  volume       = {22},
  year         = {2015},
}