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TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines

Herrera-Quiterio, Gloria Angelina ; Valencia-González, Heriberto Abraham ; de la Cruz-López, Karen Griselda ; Fernández-Coto, Diana Lashidua ; Gil, Jeovanis LU orcid ; Marko-Varga, György LU ; Morales-Gálvez, Josué ; Sánchez, Nilda C. ; Rodríguez-Bautista, Rubén and Avilés-Salas, Alejandro , et al. (2025) In International Journal of Molecular Sciences 26(3).
Abstract

The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft... (More)

The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft studies. Our findings demonstrated that TMEM160 knockdown decreased the proliferation of lung and cervical cancer cell lines. We observed that TMEM160 is localized in the nucleus and cytoplasm and dynamic localization during mitosis of cancer cells and discovered a novel interaction between TMEM160 and nuclear proteins such as NUP50. Furthermore, the TMEM160 interactome was enriched in processes associated with apical junctions, xenobiotic metabolism, glycolysis, epithelial-mesenchymal transition, reactive oxygen species, UV response DNA, the P53 pathway, and the mitotic spindle. This study provides an initial understanding of the function of TMEM160 in lung and cervical cancer progression and clarifies the need to continue investigating the participation of TMEM160 in these cancers.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-HPP, cervical cancer, non-small cell lung cancer, nuclear localization, TMEM160, tumor growth
in
International Journal of Molecular Sciences
volume
26
issue
3
article number
1097
publisher
MDPI AG
external identifiers
  • pmid:39940865
  • scopus:85217879673
ISSN
1661-6596
DOI
10.3390/ijms26031097
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 by the authors.
id
80815ffe-7e75-4ba1-b820-60a2295142a6
date added to LUP
2025-06-23 15:49:35
date last changed
2025-07-21 17:26:43
@article{80815ffe-7e75-4ba1-b820-60a2295142a6,
  abstract     = {{<p>The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft studies. Our findings demonstrated that TMEM160 knockdown decreased the proliferation of lung and cervical cancer cell lines. We observed that TMEM160 is localized in the nucleus and cytoplasm and dynamic localization during mitosis of cancer cells and discovered a novel interaction between TMEM160 and nuclear proteins such as NUP50. Furthermore, the TMEM160 interactome was enriched in processes associated with apical junctions, xenobiotic metabolism, glycolysis, epithelial-mesenchymal transition, reactive oxygen species, UV response DNA, the P53 pathway, and the mitotic spindle. This study provides an initial understanding of the function of TMEM160 in lung and cervical cancer progression and clarifies the need to continue investigating the participation of TMEM160 in these cancers.</p>}},
  author       = {{Herrera-Quiterio, Gloria Angelina and Valencia-González, Heriberto Abraham and de la Cruz-López, Karen Griselda and Fernández-Coto, Diana Lashidua and Gil, Jeovanis and Marko-Varga, György and Morales-Gálvez, Josué and Sánchez, Nilda C. and Rodríguez-Bautista, Rubén and Avilés-Salas, Alejandro and Arrieta, Oscar and García-Carrancá, Alejandro and Encarnación-Guevara, Sergio}},
  issn         = {{1661-6596}},
  keywords     = {{C-HPP; cervical cancer; non-small cell lung cancer; nuclear localization; TMEM160; tumor growth}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines}},
  url          = {{http://dx.doi.org/10.3390/ijms26031097}},
  doi          = {{10.3390/ijms26031097}},
  volume       = {{26}},
  year         = {{2025}},
}