TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines
(2025) In International Journal of Molecular Sciences 26(3).- Abstract
The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft... (More)
The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft studies. Our findings demonstrated that TMEM160 knockdown decreased the proliferation of lung and cervical cancer cell lines. We observed that TMEM160 is localized in the nucleus and cytoplasm and dynamic localization during mitosis of cancer cells and discovered a novel interaction between TMEM160 and nuclear proteins such as NUP50. Furthermore, the TMEM160 interactome was enriched in processes associated with apical junctions, xenobiotic metabolism, glycolysis, epithelial-mesenchymal transition, reactive oxygen species, UV response DNA, the P53 pathway, and the mitotic spindle. This study provides an initial understanding of the function of TMEM160 in lung and cervical cancer progression and clarifies the need to continue investigating the participation of TMEM160 in these cancers.
(Less)
- author
- organization
- publishing date
- 2025-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-HPP, cervical cancer, non-small cell lung cancer, nuclear localization, TMEM160, tumor growth
- in
- International Journal of Molecular Sciences
- volume
- 26
- issue
- 3
- article number
- 1097
- publisher
- MDPI AG
- external identifiers
-
- pmid:39940865
- scopus:85217879673
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms26031097
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 by the authors.
- id
- 80815ffe-7e75-4ba1-b820-60a2295142a6
- date added to LUP
- 2025-06-23 15:49:35
- date last changed
- 2025-07-21 17:26:43
@article{80815ffe-7e75-4ba1-b820-60a2295142a6, abstract = {{<p>The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM proteins have been implicated in cancer-related processes, including cell proliferation, migration, epithelial-mesenchymal transition, metastasis, and resistance to chemotherapy and radiotherapy. This study aimed to investigate the role of TMEM160 in non-small cell lung cancer and cervical cancer using cell lines, clinical samples, and xenograft studies. Our findings demonstrated that TMEM160 knockdown decreased the proliferation of lung and cervical cancer cell lines. We observed that TMEM160 is localized in the nucleus and cytoplasm and dynamic localization during mitosis of cancer cells and discovered a novel interaction between TMEM160 and nuclear proteins such as NUP50. Furthermore, the TMEM160 interactome was enriched in processes associated with apical junctions, xenobiotic metabolism, glycolysis, epithelial-mesenchymal transition, reactive oxygen species, UV response DNA, the P53 pathway, and the mitotic spindle. This study provides an initial understanding of the function of TMEM160 in lung and cervical cancer progression and clarifies the need to continue investigating the participation of TMEM160 in these cancers.</p>}}, author = {{Herrera-Quiterio, Gloria Angelina and Valencia-González, Heriberto Abraham and de la Cruz-López, Karen Griselda and Fernández-Coto, Diana Lashidua and Gil, Jeovanis and Marko-Varga, György and Morales-Gálvez, Josué and Sánchez, Nilda C. and Rodríguez-Bautista, Rubén and Avilés-Salas, Alejandro and Arrieta, Oscar and García-Carrancá, Alejandro and Encarnación-Guevara, Sergio}}, issn = {{1661-6596}}, keywords = {{C-HPP; cervical cancer; non-small cell lung cancer; nuclear localization; TMEM160; tumor growth}}, language = {{eng}}, number = {{3}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines}}, url = {{http://dx.doi.org/10.3390/ijms26031097}}, doi = {{10.3390/ijms26031097}}, volume = {{26}}, year = {{2025}}, }