A comparison of the human papillomavirus test and Papanicolaou smear as a second screening method for women with minor cytological abnormalities
(2005) In Acta Obstetricia et Gynecologica Scandinavica 84(10). p.996-1000- Abstract
- Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second Pap smear is obtained 4-6 months after the first one showing low-grade atypia. The aim of this study is to compare the sensitivity of human papilloma virus (HPV)-DNA testing for the detection of cervical intraepithelial neoplasia (CIN) 2-3 with that of a second Pap smear in women, who had low-grade atypia in their first Pap smear. Methods. Women... (More)
- Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second Pap smear is obtained 4-6 months after the first one showing low-grade atypia. The aim of this study is to compare the sensitivity of human papilloma virus (HPV)-DNA testing for the detection of cervical intraepithelial neoplasia (CIN) 2-3 with that of a second Pap smear in women, who had low-grade atypia in their first Pap smear. Methods. Women with low-grade atypia in the Stockholm area, detected at a population-based cytology screening, were enrolled. A repeat Pap smear, HPV test, and colposcopically directed biopsies were obtained. For the detection of HPV, Hybrid Capture II (HC II) was used. Results. The HPV-DNA test was positive in 66% of the 177 participating women. The sensitivity of the second Pap smear and HPV-DNA test to detect CIN 2-3 was 61 (95% CI = 45-74) and 82% (95% CI = 67-91), respectively. The positive and negative predictive values of HPV testing were 27 (95% CI = 18-35) and 89% (95% CI = 80-97), respectively. Conclusions. In Sweden, a second Pap smear is often obtained for the follow-up of women with low-grade atypia. The results of our study show that compared to the second Pap smear, HPV testing with HC II is a more sensitive method for detecting high-grade lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/224739
- author
- Andersson, S ; Dillner, Lena LU ; Elfgren, K ; Mints, M ; Persson, M and Rylander, E
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pap smear, CIN, HPV, screening
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 84
- issue
- 10
- pages
- 996 - 1000
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:16167918
- wos:000231901000014
- scopus:25844441585
- ISSN
- 1600-0412
- DOI
- 10.1111/j.0001-6349.2005.00702.x
- language
- English
- LU publication?
- yes
- id
- 80c3b991-745a-4ca2-899f-912ca2bdd3d5 (old id 224739)
- date added to LUP
- 2016-04-01 16:32:11
- date last changed
- 2022-01-28 20:23:12
@article{80c3b991-745a-4ca2-899f-912ca2bdd3d5, abstract = {{Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second Pap smear is obtained 4-6 months after the first one showing low-grade atypia. The aim of this study is to compare the sensitivity of human papilloma virus (HPV)-DNA testing for the detection of cervical intraepithelial neoplasia (CIN) 2-3 with that of a second Pap smear in women, who had low-grade atypia in their first Pap smear. Methods. Women with low-grade atypia in the Stockholm area, detected at a population-based cytology screening, were enrolled. A repeat Pap smear, HPV test, and colposcopically directed biopsies were obtained. For the detection of HPV, Hybrid Capture II (HC II) was used. Results. The HPV-DNA test was positive in 66% of the 177 participating women. The sensitivity of the second Pap smear and HPV-DNA test to detect CIN 2-3 was 61 (95% CI = 45-74) and 82% (95% CI = 67-91), respectively. The positive and negative predictive values of HPV testing were 27 (95% CI = 18-35) and 89% (95% CI = 80-97), respectively. Conclusions. In Sweden, a second Pap smear is often obtained for the follow-up of women with low-grade atypia. The results of our study show that compared to the second Pap smear, HPV testing with HC II is a more sensitive method for detecting high-grade lesions.}}, author = {{Andersson, S and Dillner, Lena and Elfgren, K and Mints, M and Persson, M and Rylander, E}}, issn = {{1600-0412}}, keywords = {{Pap smear; CIN; HPV; screening}}, language = {{eng}}, number = {{10}}, pages = {{996--1000}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Obstetricia et Gynecologica Scandinavica}}, title = {{A comparison of the human papillomavirus test and Papanicolaou smear as a second screening method for women with minor cytological abnormalities}}, url = {{http://dx.doi.org/10.1111/j.0001-6349.2005.00702.x}}, doi = {{10.1111/j.0001-6349.2005.00702.x}}, volume = {{84}}, year = {{2005}}, }