Advanced

Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves.

Meyer, Cora; Stenberg, Lena LU ; Gonzalez-Perez, Francisco; Wrobel, Sandra; Ronchi, Giulia; Udina, Esther; Suganuma, Seigo; Geuna, Stefano; Navarro, Xavier and Dahlin, Lars LU , et al. (2016) In Biomaterials 76. p.33-51
Abstract
Biosynthetic nerve grafts are developed in order to complement or replace autologous nerve grafts for peripheral nerve reconstruction. Artificial nerve guides currently approved for clinical use are not widely applied in reconstructive surgery as they still have limitations especially when it comes to critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan nerve guides (CNGs) enhanced by introduction of a longitudinal chitosan film to reconstruct critical length 15 mm sciatic nerve defects in adult healthy Wistar or diabetic Goto-Kakizaki rats. Short and long term investigations demonstrated that the CNGs enhanced by the guiding structure of the introduced chitosan film significantly improved functional and... (More)
Biosynthetic nerve grafts are developed in order to complement or replace autologous nerve grafts for peripheral nerve reconstruction. Artificial nerve guides currently approved for clinical use are not widely applied in reconstructive surgery as they still have limitations especially when it comes to critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan nerve guides (CNGs) enhanced by introduction of a longitudinal chitosan film to reconstruct critical length 15 mm sciatic nerve defects in adult healthy Wistar or diabetic Goto-Kakizaki rats. Short and long term investigations demonstrated that the CNGs enhanced by the guiding structure of the introduced chitosan film significantly improved functional and morphological results of nerve regeneration in comparison to simple hollow CNGs. Importantly, this was detectable both in healthy and in diabetic rats (short term) and the regeneration outcome almost reached the outcome after autologous nerve grafting (long term). Hollow CNGs provide properties likely leading to a wider clinical acceptance than other artificial nerve guides and their performance can be increased by simple introduction of a chitosan film with the same advantageous properties. Therefore, the chitosan film enhanced CNGs represent a new generation medical device for peripheral nerve reconstruction. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomaterials
volume
76
pages
33 - 51
publisher
Elsevier
external identifiers
  • pmid:26517563
  • wos:000366961100004
  • scopus:84961216065
ISSN
1878-5905
DOI
10.1016/j.biomaterials.2015.10.040
language
English
LU publication?
yes
id
064e76a7-106b-4368-89c7-f20588e334a1 (old id 8147720)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26517563?dopt=Abstract
date added to LUP
2015-11-04 21:22:41
date last changed
2017-11-19 03:19:24
@article{064e76a7-106b-4368-89c7-f20588e334a1,
  abstract     = {Biosynthetic nerve grafts are developed in order to complement or replace autologous nerve grafts for peripheral nerve reconstruction. Artificial nerve guides currently approved for clinical use are not widely applied in reconstructive surgery as they still have limitations especially when it comes to critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan nerve guides (CNGs) enhanced by introduction of a longitudinal chitosan film to reconstruct critical length 15 mm sciatic nerve defects in adult healthy Wistar or diabetic Goto-Kakizaki rats. Short and long term investigations demonstrated that the CNGs enhanced by the guiding structure of the introduced chitosan film significantly improved functional and morphological results of nerve regeneration in comparison to simple hollow CNGs. Importantly, this was detectable both in healthy and in diabetic rats (short term) and the regeneration outcome almost reached the outcome after autologous nerve grafting (long term). Hollow CNGs provide properties likely leading to a wider clinical acceptance than other artificial nerve guides and their performance can be increased by simple introduction of a chitosan film with the same advantageous properties. Therefore, the chitosan film enhanced CNGs represent a new generation medical device for peripheral nerve reconstruction.},
  author       = {Meyer, Cora and Stenberg, Lena and Gonzalez-Perez, Francisco and Wrobel, Sandra and Ronchi, Giulia and Udina, Esther and Suganuma, Seigo and Geuna, Stefano and Navarro, Xavier and Dahlin, Lars and Grothe, Claudia and Haastert-Talini, Kirsten},
  issn         = {1878-5905},
  language     = {eng},
  pages        = {33--51},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves.},
  url          = {http://dx.doi.org/10.1016/j.biomaterials.2015.10.040},
  volume       = {76},
  year         = {2016},
}