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Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.

Mori, Michiko LU ; Bjermer, Leif LU ; Erjefält, Jonas LU ; Stampfli, Martin R and Roos, Abraham LU (2015) In Respiratory Research 16.
Abstract
The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Research
volume
16
publisher
BioMed Central
external identifiers
  • pmid:26511475
  • wos:000363833700002
  • scopus:84945910415
ISSN
1465-9921
DOI
10.1186/s12931-015-0297-0
language
English
LU publication?
yes
id
3c4c6e7a-1e7c-45f7-91ef-8dca0808a733 (old id 8148043)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26511475?dopt=Abstract
date added to LUP
2015-11-04 18:16:07
date last changed
2017-01-01 03:06:23
@article{3c4c6e7a-1e7c-45f7-91ef-8dca0808a733,
  abstract     = {The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.},
  articleno    = {133},
  author       = {Mori, Michiko and Bjermer, Leif and Erjefält, Jonas and Stampfli, Martin R and Roos, Abraham},
  issn         = {1465-9921},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Respiratory Research},
  title        = {Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.},
  url          = {http://dx.doi.org/10.1186/s12931-015-0297-0},
  volume       = {16},
  year         = {2015},
}