Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.
(2015) In Respiratory Research 16.- Abstract
- The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148043
- author
- Mori, Michiko LU ; Bjermer, Leif LU ; Erjefält, Jonas LU ; Stampfli, Martin R and Roos, Abraham LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Respiratory Research
- volume
- 16
- article number
- 133
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26511475
- wos:000363833700002
- scopus:84945910415
- pmid:26511475
- ISSN
- 1465-9921
- DOI
- 10.1186/s12931-015-0297-0
- language
- English
- LU publication?
- yes
- id
- 3c4c6e7a-1e7c-45f7-91ef-8dca0808a733 (old id 8148043)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26511475?dopt=Abstract
- date added to LUP
- 2016-04-01 09:54:45
- date last changed
- 2022-03-12 00:19:26
@article{3c4c6e7a-1e7c-45f7-91ef-8dca0808a733,
abstract = {{The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.}},
author = {{Mori, Michiko and Bjermer, Leif and Erjefält, Jonas and Stampfli, Martin R and Roos, Abraham}},
issn = {{1465-9921}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Respiratory Research}},
title = {{Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.}},
url = {{https://lup.lub.lu.se/search/files/1383055/8840732}},
doi = {{10.1186/s12931-015-0297-0}},
volume = {{16}},
year = {{2015}},
}