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Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.

Chen, Ying LU ; Xu, Shu-Chang and Duan, Rui-Dong LU (2015) In Lipids in Health and Disease 14.
Abstract
Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we address a question whether increased cholesterol synthesis affects hydrolysis of SM by endogenous SMases.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lipids in Health and Disease
volume
14
article number
130
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26493087
  • wos:000363372900001
  • scopus:84944732065
  • pmid:26493087
ISSN
1476-511X
DOI
10.1186/s12944-015-0137-8
language
English
LU publication?
yes
id
50e414b5-4877-494f-9ce9-49b44b430981 (old id 8148565)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26493087?dopt=Abstract
date added to LUP
2016-04-01 13:58:16
date last changed
2025-04-04 15:36:04
@article{50e414b5-4877-494f-9ce9-49b44b430981,
  abstract     = {{Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we address a question whether increased cholesterol synthesis affects hydrolysis of SM by endogenous SMases.}},
  author       = {{Chen, Ying and Xu, Shu-Chang and Duan, Rui-Dong}},
  issn         = {{1476-511X}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Lipids in Health and Disease}},
  title        = {{Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.}},
  url          = {{https://lup.lub.lu.se/search/files/3698056/8840474}},
  doi          = {{10.1186/s12944-015-0137-8}},
  volume       = {{14}},
  year         = {{2015}},
}