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BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.

Karlsson, Jenny LU ; Valind, Anders LU and Gisselsson Nord, David LU (2016) In Genes, Chromosomes and Cancer 55(2). p.120-123
Abstract
Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. © 2015 Wiley Periodicals, Inc.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
55
issue
2
pages
120 - 123
publisher
John Wiley & Sons
external identifiers
  • pmid:26493387
  • wos:000368259600002
  • scopus:84954393741
ISSN
1045-2257
DOI
10.1002/gcc.22316
language
English
LU publication?
yes
id
36c6581d-e55c-4944-b15d-cea0b37b79e4 (old id 8148592)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26493387?dopt=Abstract
date added to LUP
2015-11-03 19:22:15
date last changed
2017-10-22 03:28:44
@article{36c6581d-e55c-4944-b15d-cea0b37b79e4,
  abstract     = {Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. © 2015 Wiley Periodicals, Inc.},
  author       = {Karlsson, Jenny and Valind, Anders and Gisselsson Nord, David},
  issn         = {1045-2257},
  language     = {eng},
  number       = {2},
  pages        = {120--123},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.},
  url          = {http://dx.doi.org/10.1002/gcc.22316},
  volume       = {55},
  year         = {2016},
}