Use of tramadol in early pregnancy and congenital malformation risk.
(2015) In Reproductive Toxicology 58(oct 16). p.246-251- Abstract
- Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a... (More)
- Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148867
- author
- Källén, Bengt LU and Reis, Margareta LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Toxicology
- volume
- 58
- issue
- oct 16
- pages
- 246 - 251
- publisher
- Elsevier
- external identifiers
-
- pmid:26482725
- wos:000367559600030
- scopus:84946724086
- pmid:26482725
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2015.10.007
- language
- English
- LU publication?
- yes
- id
- bd541da8-00d3-4cdf-987e-a1195311e83f (old id 8148867)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26482725?dopt=Abstract
- date added to LUP
- 2016-04-01 10:54:12
- date last changed
- 2022-03-12 18:07:18
@article{bd541da8-00d3-4cdf-987e-a1195311e83f,
abstract = {{Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate.}},
author = {{Källén, Bengt and Reis, Margareta}},
issn = {{1873-1708}},
language = {{eng}},
number = {{oct 16}},
pages = {{246--251}},
publisher = {{Elsevier}},
series = {{Reproductive Toxicology}},
title = {{Use of tramadol in early pregnancy and congenital malformation risk.}},
url = {{http://dx.doi.org/10.1016/j.reprotox.2015.10.007}},
doi = {{10.1016/j.reprotox.2015.10.007}},
volume = {{58}},
year = {{2015}},
}