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Use of tramadol in early pregnancy and congenital malformation risk.

Källén, Bengt LU and Reis, Margareta LU (2015) In Reproductive Toxicology 58(oct 16). p.246-251
Abstract
Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a... (More)
Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Reproductive Toxicology
volume
58
issue
oct 16
pages
246 - 251
publisher
Elsevier
external identifiers
  • pmid:26482725
  • wos:000367559600030
  • scopus:84946724086
ISSN
1873-1708
DOI
10.1016/j.reprotox.2015.10.007
language
English
LU publication?
yes
id
bd541da8-00d3-4cdf-987e-a1195311e83f (old id 8148867)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26482725?dopt=Abstract
date added to LUP
2015-11-03 18:24:41
date last changed
2017-09-17 04:02:37
@article{bd541da8-00d3-4cdf-987e-a1195311e83f,
  abstract     = {Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate.},
  author       = {Källén, Bengt and Reis, Margareta},
  issn         = {1873-1708},
  language     = {eng},
  number       = {oct 16},
  pages        = {246--251},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Use of tramadol in early pregnancy and congenital malformation risk.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2015.10.007},
  volume       = {58},
  year         = {2015},
}