Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

Yeates, Alison J; Love, Tanzy M; Engström, Karin; Mulhern, Maria S; McSorley, Emeir M; Grzesik, Katherine; Alhamdow, Ayman; Wahlberg, Karin E; Thurston, Sally W; Davidson, Philip W; van Wijngaarden, Edwin; Watson, Gene E; Shamlaye, Conrad F; Myers, G J; Strain, J J; Broberg, Karin

Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

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Yeates, Alison J ; Love, Tanzy M ; Engström, Karin ^LU ; Mulhern, Maria S ; McSorley, Emeir M ; Grzesik, Katherine ; Alhamdow, Ayman ^LU ; Wahlberg, Karin E ^LU ; Thurston, Sally W and Davidson, Philip W , et al. (2015) In Prostaglandins, Leukotrienes and Essential Fatty Acids 102-103. p.13-20

Abstract: Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and FADS2 genes to maternal LC-PUFA status and infant neurodevelopment in populations with high fish intakes. The Nutrition Cohorts 1 (NC1) and 2 (NC2) are longitudinal observational mother-child cohorts in the Republic of Seychelles. Maternal serum LC-PUFA was measured at 28 weeks gestation and genotyping for rs174537 (FADS1), rs174561... (More); Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and FADS2 genes to maternal LC-PUFA status and infant neurodevelopment in populations with high fish intakes. The Nutrition Cohorts 1 (NC1) and 2 (NC2) are longitudinal observational mother-child cohorts in the Republic of Seychelles. Maternal serum LC-PUFA was measured at 28 weeks gestation and genotyping for rs174537 (FADS1), rs174561 (FADS1), rs3834458 (FADS1-FADS2) and rs174575 (FADS2) was performed in both cohorts. The children completed the Bayley Scales of Infant Development II (BSID-II) at 30 months in NC1 and at 20 months in NC2. Complete data were available for 221 and 1310 mothers from NC1 and NC2 respectively. With increasing number of rs3834458 minor alleles, maternal concentrations of AA were significantly decreased (NC1 p=0.004; NC2 p<0.001) and precursor:product ratios for linoleic acid (LA) (18:2n-6)-to-AA (NC1 p<0.001; NC2 p<0.001) and α-linolenic acid (ALA) (18:3n-3)-to-DHA were increased (NC2 p=0.028). There were no significant associations between maternal FADS genotype and BSID-II scores in either cohort. A trend for improved PDI was found among infants born to mothers with the minor rs3834458 allele.In these high fish-eating cohorts, genetic variability in FADS genes was associated with maternal AA status measured in serum and a subtle association of the FADS genotype was found with neurodevelopment. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/8149144

author

Yeates, Alison J ; Love, Tanzy M ; Engström, Karin ^LU ; Mulhern, Maria S ; McSorley, Emeir M ; Grzesik, Katherine ; Alhamdow, Ayman ^LU ; Wahlberg, Karin E ^LU ; Thurston, Sally W and Davidson, Philip W , et al. (More)

Yeates, Alison J ; Love, Tanzy M ; Engström, Karin ^LU ; Mulhern, Maria S ; McSorley, Emeir M ; Grzesik, Katherine ; Alhamdow, Ayman ^LU ; Wahlberg, Karin E ^LU ; Thurston, Sally W ; Davidson, Philip W ; van Wijngaarden, Edwin ; Watson, Gene E ; Shamlaye, Conrad F ; Myers, G J ; Strain, J J and Broberg, Karin (Less)

organization

Division of Occupational and Environmental Medicine, Lund University

publishing date

2015

type

Contribution to journal

publication status

published

subject

in

Prostaglandins, Leukotrienes and Essential Fatty Acids

volume

102-103

pages

13 - 20

publisher

Elsevier

external identifiers

pmid:26474818
wos:000365367800003
scopus:84946744875
pmid:26474818

ISSN

0952-3278

DOI

10.1016/j.plefa.2015.08.004

language

English

LU publication?

yes

id

4ae15766-1d41-4126-90cf-ddfee80e3cfa (old id 8149144)

alternative location

http://www.ncbi.nlm.nih.gov/pubmed/26474818?dopt=Abstract

date added to LUP

2016-04-01 10:06:00

date last changed

2022-04-19 22:33:57

@article{4ae15766-1d41-4126-90cf-ddfee80e3cfa,
  abstract     = {{Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and FADS2 genes to maternal LC-PUFA status and infant neurodevelopment in populations with high fish intakes. The Nutrition Cohorts 1 (NC1) and 2 (NC2) are longitudinal observational mother-child cohorts in the Republic of Seychelles. Maternal serum LC-PUFA was measured at 28 weeks gestation and genotyping for rs174537 (FADS1), rs174561 (FADS1), rs3834458 (FADS1-FADS2) and rs174575 (FADS2) was performed in both cohorts. The children completed the Bayley Scales of Infant Development II (BSID-II) at 30 months in NC1 and at 20 months in NC2. Complete data were available for 221 and 1310 mothers from NC1 and NC2 respectively. With increasing number of rs3834458 minor alleles, maternal concentrations of AA were significantly decreased (NC1 p=0.004; NC2 p&lt;0.001) and precursor:product ratios for linoleic acid (LA) (18:2n-6)-to-AA (NC1 p&lt;0.001; NC2 p&lt;0.001) and α-linolenic acid (ALA) (18:3n-3)-to-DHA were increased (NC2 p=0.028). There were no significant associations between maternal FADS genotype and BSID-II scores in either cohort. A trend for improved PDI was found among infants born to mothers with the minor rs3834458 allele.In these high fish-eating cohorts, genetic variability in FADS genes was associated with maternal AA status measured in serum and a subtle association of the FADS genotype was found with neurodevelopment.}},
  author       = {{Yeates, Alison J and Love, Tanzy M and Engström, Karin and Mulhern, Maria S and McSorley, Emeir M and Grzesik, Katherine and Alhamdow, Ayman and Wahlberg, Karin E and Thurston, Sally W and Davidson, Philip W and van Wijngaarden, Edwin and Watson, Gene E and Shamlaye, Conrad F and Myers, G J and Strain, J J and Broberg, Karin}},
  issn         = {{0952-3278}},
  language     = {{eng}},
  pages        = {{13--20}},
  publisher    = {{Elsevier}},
  series       = {{Prostaglandins, Leukotrienes and Essential Fatty Acids}},
  title        = {{Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.}},
  url          = {{https://lup.lub.lu.se/search/files/1564237/8862712.pdf}},
  doi          = {{10.1016/j.plefa.2015.08.004}},
  volume       = {{102-103}},
  year         = {{2015}},
}

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Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.