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Preterm Children Born Small for Gestational Age are at Risk for Low Adult Bone Mass.

Buttazzoni, Christian LU ; Rosengren, Björn LU ; Tveit, Magnus LU ; Landin, Lennart LU ; Nilsson, Jan-Åke LU and Karlsson, Magnus LU (2016) In Calcified Tissue International 98(2). p.105-113
Abstract
Cross-sectional studies suggest that premature birth and low birth weight may both be associated with low peak bone mass. We followed bone traits in preterm individuals and controls for 27 years and examined the effects of birth weight relative to gestational age [stratified as small for gestational age (SGA) or appropriate for gestational (AGA)] on adult bone mineral density (BMD). We measured distal forearm BMC (g/cm) and BMD (g/cm(2)) with single-photon absorptiometry (SPA) in 46 preterm children (31 AGA and 15 SGA) at mean age 10.1 years (range 4-16) and in 84 healthy age-matched children. The measurements were repeated 27 years later with the same SPA apparatus but then also with dual energy absorptiometry and peripheral computed... (More)
Cross-sectional studies suggest that premature birth and low birth weight may both be associated with low peak bone mass. We followed bone traits in preterm individuals and controls for 27 years and examined the effects of birth weight relative to gestational age [stratified as small for gestational age (SGA) or appropriate for gestational (AGA)] on adult bone mineral density (BMD). We measured distal forearm BMC (g/cm) and BMD (g/cm(2)) with single-photon absorptiometry (SPA) in 46 preterm children (31 AGA and 15 SGA) at mean age 10.1 years (range 4-16) and in 84 healthy age-matched children. The measurements were repeated 27 years later with the same SPA apparatus but then also with dual energy absorptiometry and peripheral computed tomography (pQCT). Preterm individuals were shorter (p = 0.03) in adulthood than controls. Preterm AGA individuals had similar BMC and BMD height-adjusted Z-scores in adulthood compared to controls. Preterm SGA individuals had lower distal forearm BMC and BMD height-adjusted Z-scores in adulthood than both controls and preterm AGA individuals. Preterm SGA individuals had lower gain from childhood to adulthood in distal forearm BMC height-adjusted Z-scores than controls (p = 0.03). The deficits in preterm SGA individuals in adulthood were also captured by DEXA in height-adjusted femoral neck (FN) BMC Z-score and height-adjusted FN BMD Z-score and by pQCT in tibial cross-sectional area (CSA) Z-score and stress strain index (SSI) Z-score, where all measurements were lower than controls (all p values <0.05). Preterm SGA individuals are at increased risk of reaching low adult bone mass, at least partly due to a deficit in the accrual of bone mineral during growth. In our cohort, we were unable to find a similar risk in preterm AGA individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Calcified Tissue International
volume
98
issue
2
pages
105 - 113
publisher
Springer
external identifiers
  • pmid:26472429
  • wos:000368823000001
  • scopus:84955752780
ISSN
1432-0827
DOI
10.1007/s00223-015-0069-3
language
English
LU publication?
yes
id
506aecde-0bc1-43b5-bbd7-2ee0efaef338 (old id 8152113)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26472429?dopt=Abstract
date added to LUP
2015-11-03 15:09:52
date last changed
2017-07-30 03:28:06
@article{506aecde-0bc1-43b5-bbd7-2ee0efaef338,
  abstract     = {Cross-sectional studies suggest that premature birth and low birth weight may both be associated with low peak bone mass. We followed bone traits in preterm individuals and controls for 27 years and examined the effects of birth weight relative to gestational age [stratified as small for gestational age (SGA) or appropriate for gestational (AGA)] on adult bone mineral density (BMD). We measured distal forearm BMC (g/cm) and BMD (g/cm(2)) with single-photon absorptiometry (SPA) in 46 preterm children (31 AGA and 15 SGA) at mean age 10.1 years (range 4-16) and in 84 healthy age-matched children. The measurements were repeated 27 years later with the same SPA apparatus but then also with dual energy absorptiometry and peripheral computed tomography (pQCT). Preterm individuals were shorter (p = 0.03) in adulthood than controls. Preterm AGA individuals had similar BMC and BMD height-adjusted Z-scores in adulthood compared to controls. Preterm SGA individuals had lower distal forearm BMC and BMD height-adjusted Z-scores in adulthood than both controls and preterm AGA individuals. Preterm SGA individuals had lower gain from childhood to adulthood in distal forearm BMC height-adjusted Z-scores than controls (p = 0.03). The deficits in preterm SGA individuals in adulthood were also captured by DEXA in height-adjusted femoral neck (FN) BMC Z-score and height-adjusted FN BMD Z-score and by pQCT in tibial cross-sectional area (CSA) Z-score and stress strain index (SSI) Z-score, where all measurements were lower than controls (all p values &lt;0.05). Preterm SGA individuals are at increased risk of reaching low adult bone mass, at least partly due to a deficit in the accrual of bone mineral during growth. In our cohort, we were unable to find a similar risk in preterm AGA individuals.},
  author       = {Buttazzoni, Christian and Rosengren, Björn and Tveit, Magnus and Landin, Lennart and Nilsson, Jan-Åke and Karlsson, Magnus},
  issn         = {1432-0827},
  language     = {eng},
  number       = {2},
  pages        = {105--113},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Preterm Children Born Small for Gestational Age are at Risk for Low Adult Bone Mass.},
  url          = {http://dx.doi.org/10.1007/s00223-015-0069-3},
  volume       = {98},
  year         = {2016},
}