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Soluble urokinase plasminogen activator receptor and incidence of venous thromboembolism.

Engström, Gunnar LU ; Zöller, Bengt LU orcid ; Svensson, Peter LU ; Melander, Olle LU orcid and Persson, Margaretha LU orcid (2015) In Thrombosis and Haemostasis 115(3). p.657-662
Abstract
Raised plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) have been associated with increased incidence of cardiovascular diseases. Whether suPAR is associated with venous thromboembolism (VTE) is largely unknown. The purpose of the present study was to investigate the relationship between suPAR and incidence of VTE in a cohort study. suPAR was measured in 5,203 subjects (aged 46-68 years, 58 % women) from the general population, who participated in the Malmö Diet and Cancer (MDC) study between 1991 and 1994. Incident cases of VTE were identified from the Swedish patient register during a mean follow-up of 15.7 years. Of 5,203 subjects with measurements of suPAR, 239 had VTE during follow-up (127 venous... (More)
Raised plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) have been associated with increased incidence of cardiovascular diseases. Whether suPAR is associated with venous thromboembolism (VTE) is largely unknown. The purpose of the present study was to investigate the relationship between suPAR and incidence of VTE in a cohort study. suPAR was measured in 5,203 subjects (aged 46-68 years, 58 % women) from the general population, who participated in the Malmö Diet and Cancer (MDC) study between 1991 and 1994. Incident cases of VTE were identified from the Swedish patient register during a mean follow-up of 15.7 years. Of 5,203 subjects with measurements of suPAR, 239 had VTE during follow-up (127 venous thrombosis, 86 lung embolism, 26 both). Incidence of VTE was significantly higher in subjects with suPAR levels in the top quartile. Adjusted for age and sex, the HR (4th vs 1st quartile) was 1.74 (95 %CI: 1.2-2.6, p for trend=0.003). After adjustments for risk factors, the HR was 1.66 (95 %CI: 1.1-2.5, p for trend=0.016). High level of suPAR was a risk indicator for incidence of VTE in this population-based cohort study. The causal relationships between suPAR and VTE remain to be explored. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis and Haemostasis
volume
115
issue
3
pages
657 - 662
publisher
Schattauer GmbH
external identifiers
  • pmid:26466866
  • wos:000371777000022
  • scopus:84964744630
  • pmid:26466866
ISSN
0340-6245
DOI
10.1160/TH15-06-0511
language
English
LU publication?
yes
id
9f277f8a-b68d-4312-b1a7-f885b51434f1 (old id 8152339)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26466866?dopt=Abstract
date added to LUP
2016-04-04 09:05:04
date last changed
2024-01-12 07:40:57
@article{9f277f8a-b68d-4312-b1a7-f885b51434f1,
  abstract     = {{Raised plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) have been associated with increased incidence of cardiovascular diseases. Whether suPAR is associated with venous thromboembolism (VTE) is largely unknown. The purpose of the present study was to investigate the relationship between suPAR and incidence of VTE in a cohort study. suPAR was measured in 5,203 subjects (aged 46-68 years, 58 % women) from the general population, who participated in the Malmö Diet and Cancer (MDC) study between 1991 and 1994. Incident cases of VTE were identified from the Swedish patient register during a mean follow-up of 15.7 years. Of 5,203 subjects with measurements of suPAR, 239 had VTE during follow-up (127 venous thrombosis, 86 lung embolism, 26 both). Incidence of VTE was significantly higher in subjects with suPAR levels in the top quartile. Adjusted for age and sex, the HR (4th vs 1st quartile) was 1.74 (95 %CI: 1.2-2.6, p for trend=0.003). After adjustments for risk factors, the HR was 1.66 (95 %CI: 1.1-2.5, p for trend=0.016). High level of suPAR was a risk indicator for incidence of VTE in this population-based cohort study. The causal relationships between suPAR and VTE remain to be explored.}},
  author       = {{Engström, Gunnar and Zöller, Bengt and Svensson, Peter and Melander, Olle and Persson, Margaretha}},
  issn         = {{0340-6245}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{657--662}},
  publisher    = {{Schattauer GmbH}},
  series       = {{Thrombosis and Haemostasis}},
  title        = {{Soluble urokinase plasminogen activator receptor and incidence of venous thromboembolism.}},
  url          = {{http://dx.doi.org/10.1160/TH15-06-0511}},
  doi          = {{10.1160/TH15-06-0511}},
  volume       = {{115}},
  year         = {{2015}},
}