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Uncertainty propagation for SPECT/CT-based renal dosimetry in (177)Lu peptide receptor radionuclide therapy.

Gustafsson, Johan Ruben LU ; Brolin, Gustav LU ; Cox, Maurice; Ljungberg, Michael LU ; Johansson, Lena and Sjögreen Gleisner, Katarina LU (2015) In Physics in Medicine and Biology 60(21). p.8329-8346
Abstract
A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and... (More)
A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and integration to absorbed dose and BED. By introducing variabilities in these steps the combined uncertainty in the output quantity is determined. The importance of different sources of uncertainty is assessed by observing the decrease in standard deviation when removing a particular source. The obtained absorbed dose and BED standard deviations are approximately 6% and slightly higher if considering the root mean square error. The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
60
issue
21
pages
8329 - 8346
publisher
IOP Publishing
external identifiers
  • pmid:26458139
  • wos:000366108500009
  • scopus:84946073658
ISSN
1361-6560
DOI
10.1088/0031-9155/60/21/8329
language
English
LU publication?
yes
id
122e1f35-fb9c-4229-9638-d2601f89c451 (old id 8152549)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26458139?dopt=Abstract
date added to LUP
2015-11-03 12:05:00
date last changed
2017-11-19 03:20:34
@article{122e1f35-fb9c-4229-9638-d2601f89c451,
  abstract     = {A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and integration to absorbed dose and BED. By introducing variabilities in these steps the combined uncertainty in the output quantity is determined. The importance of different sources of uncertainty is assessed by observing the decrease in standard deviation when removing a particular source. The obtained absorbed dose and BED standard deviations are approximately 6% and slightly higher if considering the root mean square error. The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity.},
  author       = {Gustafsson, Johan Ruben and Brolin, Gustav and Cox, Maurice and Ljungberg, Michael and Johansson, Lena and Sjögreen Gleisner, Katarina},
  issn         = {1361-6560},
  language     = {eng},
  number       = {21},
  pages        = {8329--8346},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Uncertainty propagation for SPECT/CT-based renal dosimetry in (177)Lu peptide receptor radionuclide therapy.},
  url          = {http://dx.doi.org/10.1088/0031-9155/60/21/8329},
  volume       = {60},
  year         = {2015},
}