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Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.

Svensson, Daniel LU ; Nebel, Daniel LU and Nilsson, Bengt-Olof LU (2016) In Inflammation Research 65(1). p.25-32
Abstract
The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple... (More)
The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammation Research
volume
65
issue
1
pages
25 - 32
publisher
Birkhaüser
external identifiers
  • pmid:26433491
  • wos:000367918300003
  • scopus:84952990075
ISSN
1420-908X
DOI
10.1007/s00011-015-0884-z
language
English
LU publication?
yes
id
fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f (old id 8158966)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26433491?dopt=Abstract
date added to LUP
2015-11-02 16:45:19
date last changed
2017-11-05 03:00:08
@article{fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f,
  abstract     = {The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.},
  author       = {Svensson, Daniel and Nebel, Daniel and Nilsson, Bengt-Olof},
  issn         = {1420-908X},
  language     = {eng},
  number       = {1},
  pages        = {25--32},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research},
  title        = {Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.},
  url          = {http://dx.doi.org/10.1007/s00011-015-0884-z},
  volume       = {65},
  year         = {2016},
}