Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.
(2016) In Inflammation Research 65(1). p.25-32- Abstract
- The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple... (More)
- The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8158966
- author
- Svensson, Daniel LU ; Nebel, Daniel LU and Nilsson, Bengt-Olof LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Inflammation Research
- volume
- 65
- issue
- 1
- pages
- 25 - 32
- publisher
- Birkhäuser
- external identifiers
-
- pmid:26433491
- wos:000367918300003
- scopus:84952990075
- pmid:26433491
- ISSN
- 1420-908X
- DOI
- 10.1007/s00011-015-0884-z
- project
- Vitamin D and estrogen receptor signaling
- language
- English
- LU publication?
- yes
- id
- fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f (old id 8158966)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26433491?dopt=Abstract
- date added to LUP
- 2016-04-01 09:47:33
- date last changed
- 2024-06-30 01:54:24
@article{fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f, abstract = {{The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.}}, author = {{Svensson, Daniel and Nebel, Daniel and Nilsson, Bengt-Olof}}, issn = {{1420-908X}}, language = {{eng}}, number = {{1}}, pages = {{25--32}}, publisher = {{Birkhäuser}}, series = {{Inflammation Research}}, title = {{Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.}}, url = {{https://lup.lub.lu.se/search/files/1246091/8869675.pdf}}, doi = {{10.1007/s00011-015-0884-z}}, volume = {{65}}, year = {{2016}}, }