Analysis of anti-C1q autoantibodies by western blot
(2019) In Methods in Molecular Biology 1901. p.183-189- Abstract
Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions. Results may help clinicians to differentiate between SLE and HUVS.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/81b104d2-9d64-4428-a7e3-789f73fb3e4f
- author
- Verlemyr, Anci ; Truedsson, Lennart LU and Skattum, Lillemor LU
- organization
- publishing date
- 2019
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Anti-C1q autoantibodies, C1q protein chains B and C, Hypocomplementemic urticarial vasculitis syndrome, Systemic lupus erythematosus, Western blot
- host publication
- Methods in Molecular Biology
- series title
- Methods in Molecular Biology
- volume
- 1901
- pages
- 7 pages
- publisher
- Humana Press
- external identifiers
-
- pmid:30539577
- scopus:85058611402
- ISSN
- 1064-3745
- DOI
- 10.1007/978-1-4939-8949-2_14
- language
- English
- LU publication?
- yes
- id
- 81b104d2-9d64-4428-a7e3-789f73fb3e4f
- date added to LUP
- 2019-01-02 14:39:50
- date last changed
- 2024-09-17 11:03:48
@inbook{81b104d2-9d64-4428-a7e3-789f73fb3e4f, abstract = {{<p>Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions. Results may help clinicians to differentiate between SLE and HUVS.</p>}}, author = {{Verlemyr, Anci and Truedsson, Lennart and Skattum, Lillemor}}, booktitle = {{Methods in Molecular Biology}}, issn = {{1064-3745}}, keywords = {{Anti-C1q autoantibodies; C1q protein chains B and C; Hypocomplementemic urticarial vasculitis syndrome; Systemic lupus erythematosus; Western blot}}, language = {{eng}}, pages = {{183--189}}, publisher = {{Humana Press}}, series = {{Methods in Molecular Biology}}, title = {{Analysis of anti-C1q autoantibodies by western blot}}, url = {{http://dx.doi.org/10.1007/978-1-4939-8949-2_14}}, doi = {{10.1007/978-1-4939-8949-2_14}}, volume = {{1901}}, year = {{2019}}, }