The role of p-c-Jun in survival and outgrowth of developing sensory neurons
(2005) In NeuroReport 16(15). p.1655-1659- Abstract
- c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun... (More)
- c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/214182
- author
- Lindwall, Charlotta LU and Kanje, Martin LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- nerve growth, dorsal root ganglia, development, c-Jun, (D)-JNKII, rat, factor
- in
- NeuroReport
- volume
- 16
- issue
- 15
- pages
- 1655 - 1659
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:16189472
- wos:000233073900009
- scopus:29144475318
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- id
- 81b12a3b-a72b-42a3-85e9-610d932a4dc9 (old id 214182)
- date added to LUP
- 2016-04-01 11:49:22
- date last changed
- 2022-01-26 18:46:51
@article{81b12a3b-a72b-42a3-85e9-610d932a4dc9,
abstract = {{c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.}},
author = {{Lindwall, Charlotta and Kanje, Martin}},
issn = {{1473-558X}},
keywords = {{nerve growth; dorsal root ganglia; development; c-Jun; (D)-JNKII; rat; factor}},
language = {{eng}},
number = {{15}},
pages = {{1655--1659}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{The role of p-c-Jun in survival and outgrowth of developing sensory neurons}},
volume = {{16}},
year = {{2005}},
}