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Tumors of bone

Mertens, Fredrik LU and Mandahl, Nils LU (2015) In Cancer Cytogenetics p.566-582
Abstract

Bone tumors constitute a heterogeneous group of neoplasms of skeletal origin. Benign cartilage tumors include osteochondroma, subungual exostosis, bizarre parosteal osteochondromatous proliferation (BPOP), chondromas, synovial chondromatosis, chondroblastoma, and chondromyxoid fibroma. Ewing sarcomas, also known as primitive neuroectodermal tumors (PNET), are highly aggressive small cell round cell sarcomas showing varying degrees of neuroectodermal differentiation. Giant cell tumor of bone is a benign but locally aggressive tumor accounting for approximately 5% of all bone tumors. Cytogenetic analyses of bone tumors have demonstrated that most subtypes carry characteristic, sometimes tumor-specific, chromosomal aberrations that are... (More)

Bone tumors constitute a heterogeneous group of neoplasms of skeletal origin. Benign cartilage tumors include osteochondroma, subungual exostosis, bizarre parosteal osteochondromatous proliferation (BPOP), chondromas, synovial chondromatosis, chondroblastoma, and chondromyxoid fibroma. Ewing sarcomas, also known as primitive neuroectodermal tumors (PNET), are highly aggressive small cell round cell sarcomas showing varying degrees of neuroectodermal differentiation. Giant cell tumor of bone is a benign but locally aggressive tumor accounting for approximately 5% of all bone tumors. Cytogenetic analyses of bone tumors have demonstrated that most subtypes carry characteristic, sometimes tumor-specific, chromosomal aberrations that are useful for differential diagnostic purposes. Many of the tumor-specific chromosomal rearrangements are balanced translocations, and for the majority of them, the molecular consequences have been clarified, allowing the use of fluorescence in situ hybridization (FISH) or reverse transcription polymerase chain reaction (RT-PCR) to verify or exclude their presence preoperatively or before initiating chemotherapy.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cartilage tumors, Cytogenetic analyses, Ewing sarcoma, Giant cell tumors, Notochordal tumors, Osteogenic tumors
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix; and
pages
17 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015886966
ISBN
9781118795569
9781118795538
DOI
10.1002/9781118795569.ch23
language
English
LU publication?
yes
id
81b8bab0-f2b7-4d50-aca7-ccdb7ac786f2
date added to LUP
2017-04-20 10:42:53
date last changed
2017-04-20 10:42:53
@inbook{81b8bab0-f2b7-4d50-aca7-ccdb7ac786f2,
  abstract     = {<p>Bone tumors constitute a heterogeneous group of neoplasms of skeletal origin. Benign cartilage tumors include osteochondroma, subungual exostosis, bizarre parosteal osteochondromatous proliferation (BPOP), chondromas, synovial chondromatosis, chondroblastoma, and chondromyxoid fibroma. Ewing sarcomas, also known as primitive neuroectodermal tumors (PNET), are highly aggressive small cell round cell sarcomas showing varying degrees of neuroectodermal differentiation. Giant cell tumor of bone is a benign but locally aggressive tumor accounting for approximately 5% of all bone tumors. Cytogenetic analyses of bone tumors have demonstrated that most subtypes carry characteristic, sometimes tumor-specific, chromosomal aberrations that are useful for differential diagnostic purposes. Many of the tumor-specific chromosomal rearrangements are balanced translocations, and for the majority of them, the molecular consequences have been clarified, allowing the use of fluorescence in situ hybridization (FISH) or reverse transcription polymerase chain reaction (RT-PCR) to verify or exclude their presence preoperatively or before initiating chemotherapy.</p>},
  author       = {Mertens, Fredrik and Mandahl, Nils},
  editor       = {Heim, Sverre and Mitelman, Felix},
  isbn         = {9781118795569},
  keyword      = {Cartilage tumors,Cytogenetic analyses,Ewing sarcoma,Giant cell tumors,Notochordal tumors,Osteogenic tumors},
  language     = {eng},
  pages        = {566--582},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Tumors of bone},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch23},
  year         = {2015},
}