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The effect of schizophrenia on length of in-hospital stay and major adverse cardiac events following acute coronary syndrome in Denmark

Attar, Rubina LU ; Valentin, J B ; Aagaard, J and Jensen, S E (2018) In European Heart Journal 39(1).
Abstract
Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.

Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow... (More)
Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.

Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow spectrum schizophrenia ICD-10 F20. The patients were matched 1:2 to a PHC population on gender, age and year of first ACS diagnosis. The LoS, as well as the effect of schizophrenia on major adverse cardiac events (MACE: stroke, reinfarction and all-cause mortality) was investigated using cox regression analyses.

Results: A total of 1,572 patients were analysed (schizophrenia: n=524), 65.27% of the population were males and the mean age was 61.13 years. There was no difference in LoS (p>0.05) between the populations. Patients with schizophrenia had a higher prevalence of cardiac risk factors such as anemia and diabetes mellitus. Having schizophrenia had a significant effect on stroke (HR 1.47, 95% CI: 1.29–1.68)) and all-cause mortality rates (HR 2.69, 95% CI: 2.25–3.20). The results for the individual ACS diagnoses can be found in Table 1. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute coronary syndromes, cardiac event, schizophrenia
in
European Heart Journal
volume
39
issue
1
publisher
Oxford University Press
ISSN
1522-9645
DOI
10.1093/eurheartj/ehy563.P4431
language
English
LU publication?
no
id
81fd32da-694e-4b7c-82aa-24eb9fa168c5
date added to LUP
2019-04-02 13:22:44
date last changed
2019-04-02 14:02:32
@misc{81fd32da-694e-4b7c-82aa-24eb9fa168c5,
  abstract     = {Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.<br>
<br>
Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow spectrum schizophrenia ICD-10 F20. The patients were matched 1:2 to a PHC population on gender, age and year of first ACS diagnosis. The LoS, as well as the effect of schizophrenia on major adverse cardiac events (MACE: stroke, reinfarction and all-cause mortality) was investigated using cox regression analyses.<br>
<br>
Results: A total of 1,572 patients were analysed (schizophrenia: n=524), 65.27% of the population were males and the mean age was 61.13 years. There was no difference in LoS (p&gt;0.05) between the populations. Patients with schizophrenia had a higher prevalence of cardiac risk factors such as anemia and diabetes mellitus. Having schizophrenia had a significant effect on stroke (HR 1.47, 95% CI: 1.29–1.68)) and all-cause mortality rates (HR 2.69, 95% CI: 2.25–3.20). The results for the individual ACS diagnoses can be found in Table 1.},
  author       = {Attar, Rubina and Valentin, J B and Aagaard, J and Jensen, S E },
  issn         = {1522-9645},
  language     = {eng},
  note         = {Conference Abstract},
  number       = {1},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {The effect of schizophrenia on length of in-hospital stay and major adverse cardiac events following acute coronary syndrome in Denmark},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehy563.P4431},
  doi          = {10.1093/eurheartj/ehy563.P4431},
  volume       = {39},
  year         = {2018},
}