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Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles

Soderlund, Hugo; Mousavi, Monirehalsadat LU ; Liu, Haichun LU and Andersson-Engels, Stefan LU (2015) In Journal of Biomedical Optics 20(8).
Abstract
Ytterbium (Yb3+)-sensitized upconverting nanoparticles (UCNPs) are excited at 975 nm causing relatively high absorption in tissue. A new type of UCNPs with neodymium (Nd3+) and Yb3+ codoping is excitable at a 808-nm wavelength. At this wavelength, the tissue absorption is lower. Here we quantify, both experimentally and theoretically, to what extent Nd3+-doped UCNPs will provide an increased signal at larger depths in tissue compared to conventional 975-nm excited UCNPs. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
upconverting nanoparticles, tissue optics, deep tissue imaging
in
Journal of Biomedical Optics
volume
20
issue
8
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000362516700019
  • scopus:84939250080
ISSN
1083-3668
DOI
10.1117/1.JBO.20.8.086008
language
English
LU publication?
yes
id
c2a987e5-f993-4442-9e5c-c8ea177bae93 (old id 8220515)
date added to LUP
2015-11-30 07:56:05
date last changed
2017-07-30 03:14:04
@article{c2a987e5-f993-4442-9e5c-c8ea177bae93,
  abstract     = {Ytterbium (Yb3+)-sensitized upconverting nanoparticles (UCNPs) are excited at 975 nm causing relatively high absorption in tissue. A new type of UCNPs with neodymium (Nd3+) and Yb3+ codoping is excitable at a 808-nm wavelength. At this wavelength, the tissue absorption is lower. Here we quantify, both experimentally and theoretically, to what extent Nd3+-doped UCNPs will provide an increased signal at larger depths in tissue compared to conventional 975-nm excited UCNPs. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.},
  articleno    = {086008},
  author       = {Soderlund, Hugo and Mousavi, Monirehalsadat and Liu, Haichun and Andersson-Engels, Stefan},
  issn         = {1083-3668},
  keyword      = {upconverting nanoparticles,tissue optics,deep tissue imaging},
  language     = {eng},
  number       = {8},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles},
  url          = {http://dx.doi.org/10.1117/1.JBO.20.8.086008},
  volume       = {20},
  year         = {2015},
}