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A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Ingegnoli, Francesca; Boracchi, Patrizia; Gualtierotti, Roberta; Smith, Vanessa; Cutolo, Maurizio; Foeldvari, Ivan; Airo, Paolo; Jose Alegre-Sancho, Juan; Allanore, Yannick and Ananieva, Lidia P., et al. (2015) In Microvascular Research 102. p.19-24
Abstract
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active... (More)
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% Cl 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% Cl 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of sderoderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue. (C) 2015 Elsevier Inc. All rights reserved. (Less)
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keywords
Capillaroscopy, Juvenile systemic sclerosis, EUSTAR, Systemic sclerosis, Microcirculation, Nailfold capillaroscopy, Videocapillaroscopy
in
Microvascular Research
volume
102
pages
19 - 24
publisher
Academic Press
external identifiers
  • wos:000362310700004
  • scopus:84943651729
ISSN
1095-9319
DOI
10.1016/j.mvr.2015.07.007
language
English
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yes
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03adb60e-6d46-47a5-8937-28369e799502 (old id 8220913)
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2015-11-30 13:30:28
date last changed
2017-07-02 03:21:04
@article{03adb60e-6d46-47a5-8937-28369e799502,
  abstract     = {Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% Cl 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% Cl 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of sderoderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue. (C) 2015 Elsevier Inc. All rights reserved.},
  author       = {Ingegnoli, Francesca and Boracchi, Patrizia and Gualtierotti, Roberta and Smith, Vanessa and Cutolo, Maurizio and Foeldvari, Ivan and Airo, Paolo and Jose Alegre-Sancho, Juan and Allanore, Yannick and Ananieva, Lidia P. and Ancuta, Codrina and Andrade, Luis Eduardo and Aringer, Martin and Becvar, Radim and Bojinca, Mihai and Butrimiene, Irena and Cantatore, Francesco Paolo and Caporali, Roberto and Caramaschi, Paola and Carreira, Patricia E. and Chirieac, Rodica and Corrado, Ada and Cosentino, Vanesa and Cuomo, Giovanna and Czirjak, Laszlo and Pereira Da Silva, Jose Antonio and de la Pena Lefebvre, Paloma Garcia and De Keyser, Filip and Mueller, Carolina de Souza and Damgaard, Kirsten and Damjanov, Nemanja and Denisov, Lev N. and Distler, Oliver and Doube, Alan and Dumitrascu, Alina and Engelhart, Merete and Exposito, Marta Valero and Eyerich, Kilian and Farge-Bancel, Dominique and Azevedo, Valderilio Feijo and Foti, Rosario and Frerix, Marc and Gabrielli, Armando and Garen, Torhild and Gottschalk, Paola and Groseanu, Laura and Guiducci, Serena and Guenther, Claudia and Hachulla, Eric and Hein, Ruediger and Heitmann, Stefan and Henes, Joerg and Hesselstrand, Roger and Highton, John and Lannone, Florenzo and Ionescu, Ruxandra Maria and Kayser, Cristiane and Karpec, Diana and Kerzberg, Eduardo and Kotulska, Anna and Kopec-Medrek, Magdalena and Kucharz, Eugene and Krummel-Lorenz, Brigitte and Lauffer, Felix and Launay, David and Li, Mengtao and Litinsky, Ira and Loyo, Esthela and Cerinic, Marco Matucci and Meroni, Pierluigi and Midtvedt, Oyvind and Mihai, Carmen Marina and Montecucco, Carlomaurizio and Montoya, Fabiana and Morgiel, Ewa and Mouthon, Luc and Mueller-Ladner, Ulf and Nielsen, Henrik and Opris, Daniela and Ortiz-Santamaria, Vera and Otsa, Kati and Pileckyte, Margarita and Pisarri, Simonetta and Popescu, Monica and Pozzi, Maria Rosa and Puppo, Francesco and Radominski, Sebastiao Cezar and Riccieri, Valeria and Rosato, Edoardo and Rozman, Blaz and Rubio, Silvia Rodriguez and Rugiene, Rita and Saar, Petra and Salvador, Maria Joao and Seidel, Matthias and Sokolik, Renata and Solanki, Kamal and Stamenkovic, Bojana and Stankovic, Aleksandra and Stebbings, Simon and Strauss, Gitte and Sulli, Alberto and Szamosi, Szilvia and Szechinski, Jacek and Szmyrka-Kaczmarek, Magdalena and Szuecs, Gabriella and Tanaseanu, Cristina-Mihaela and Tiglea, Isabela and Tyndall, Alan and Ughi, Nicola and Uprus, Maria and Vacca, Alessandra and Varju, Cecilia and Venalis, Algirdas and Venalis, Paulius and Walker, Ulrich A. and Widuchowska, Malgorzata and Wiland, Piotr and Wuttge, Dirk and Zeni, Silvana and Zenone, Thierry},
  issn         = {1095-9319},
  keyword      = {Capillaroscopy,Juvenile systemic sclerosis,EUSTAR,Systemic sclerosis,Microcirculation,Nailfold capillaroscopy,Videocapillaroscopy},
  language     = {eng},
  pages        = {19--24},
  publisher    = {Academic Press},
  series       = {Microvascular Research},
  title        = {A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study},
  url          = {http://dx.doi.org/10.1016/j.mvr.2015.07.007},
  volume       = {102},
  year         = {2015},
}