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Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis.

Guerra, Maria Eduarda Souza ; Destro, Giulia ; Vieira, Brenda ; Lima, Alice S ; Ferraz, Lucio Fabio Caldas ; Hakansson, Anders P LU orcid ; Darrieux, Michelle LU and Converso, Thiago Rojas LU (2022) In Frontiers in cellular and infection microbiology 12. p.1-13
Abstract

The ability to form biofilms is a crucial virulence trait for several microorganisms, including
Klebsiella pneumoniae - a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of
K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We... (More)

The ability to form biofilms is a crucial virulence trait for several microorganisms, including
Klebsiella pneumoniae - a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of
K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in
K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of
in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-Bacterial Agents/pharmacology, Bacterial Infections, Biofilms, Humans, Klebsiella pneumoniae/genetics, Virulence
in
Frontiers in cellular and infection microbiology
volume
12
article number
877995
pages
1 - 13
publisher
Frontiers Media S. A.
external identifiers
  • pmid:35646720
  • scopus:85131126579
ISSN
2235-2988
DOI
10.3389/fcimb.2022.877995
language
English
LU publication?
yes
additional info
Copyright © 2022 Guerra, Destro, Vieira, Lima, Ferraz, Hakansson, Darrieux and Converso.
id
822cd857-bff8-405a-b0dc-0e82b1258e17
date added to LUP
2022-06-09 16:16:06
date last changed
2024-04-18 08:59:48
@article{822cd857-bff8-405a-b0dc-0e82b1258e17,
  abstract     = {{<p>The ability to form biofilms is a crucial virulence trait for several microorganisms, including <br>
 Klebsiella pneumoniae - a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of<br>
 K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in <br>
 K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of <br>
 in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection.<br>
 </p>}},
  author       = {{Guerra, Maria Eduarda Souza and Destro, Giulia and Vieira, Brenda and Lima, Alice S and Ferraz, Lucio Fabio Caldas and Hakansson, Anders P and Darrieux, Michelle and Converso, Thiago Rojas}},
  issn         = {{2235-2988}},
  keywords     = {{Anti-Bacterial Agents/pharmacology; Bacterial Infections; Biofilms; Humans; Klebsiella pneumoniae/genetics; Virulence}},
  language     = {{eng}},
  pages        = {{1--13}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in cellular and infection microbiology}},
  title        = {{Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis.}},
  url          = {{http://dx.doi.org/10.3389/fcimb.2022.877995}},
  doi          = {{10.3389/fcimb.2022.877995}},
  volume       = {{12}},
  year         = {{2022}},
}